Chitinases as a potential diagnostic and prognostic biomarker for amyotrophic lateral sclerosis: a systematic review and meta-analysis

被引:0
作者
Aoling Xu
Yujun Luo
Yudi Tang
Fen Yang
Xiaolian Gao
Guiyuan Qiao
Xinhong Zhu
Jing Zhou
机构
[1] Hubei University of Chinese Medicine,School of Acupuncture
[2] Hubei Provincial Hospital of Traditional Chinese Medicine,Moxibustion and Orthopedics
[3] Affiliated Hospital of Hubei University of Chinese Medicine,Department of Tuina and Rehabilitation Medicine
[4] Hubei Provincial Institute of Traditional Chinese Medicine,Department of Tuina and Rehabilitation Medicine
[5] Hubei University of Chinese Medicine,Department of Tuina and Rehabilitation Medicine
[6] Hubei University of Chinese Medicine,First Clinical Medical College
来源
Neurological Sciences | 2024年 / 45卷
关键词
Amyotrophic lateral sclerosis; CHIT1; CHI3L1; CHI3L2; Biomarker; Cerebrospinal fluid; Blood;
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摘要
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the degeneration of motor neurons, and there is currently a lack of reliable diagnostic biomarkers. This meta-analysis aimed to evaluate CHIT1, CHI3L1, and CHI3L2 levels in the cerebrospinal fluid (CSF) or blood and their diagnostic potential in ALS patients. A systematic, comprehensive search was performed of peer-reviewed English-language articles published before April 1, 2023, in PubMed, Scopus, Embase, Cochrane Library, and Web of Science. After a thorough screening, 13 primary articles were included, and their chitinases-related data were extracted for systematic review and meta-analysis. In ALS patients, the CSF CHIT1 levels were significantly elevated compared to controls with healthy control (HC) (SMD, 1.92; 95% CI, 0.78 – 3.06; P < 0.001). CHIT1 levels were elevated in the CSF of ALS patients compared to other neurodegenerative diseases (ONDS) control (SMD, 0.74; 95% CI, 0.22 – 1.27; P < 0.001) and exhibited an even more substantial increase when compared to ALS-mimicking diseases (AMDS) (SMD, 1.15; 95% CI, 0.35 – 1.94, P < 0.001). Similarly, the CSF CHI3L1 levels were significantly higher in ALS patients compared to HC (SMD, 3.16; 95% CI, 1.26 – 5.06, P < 0.001). CHI3L1 levels were elevated in the CSF of ALS patients compared to ONDS (SMD, 0.75; 95% CI, 0.32 – 1.19; P = 0.017) and exhibited a more pronounced increase when compared to AMDS (SMD, 1.92; 95% CI, 0.41 – 3.42; P < 0.001). The levels of CSF chitinases in the ALS patients showed a significant increase, supporting the role of CSF chitinases as diagnostic biomarkers for ALS.
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页码:2489 / 2503
页数:14
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