Frequency of Spontaneous BOLD Signal Differences between Moderate and Late Preterm Newborns and Term Newborns

被引：0
作者：
Xiushuang Wu
Luqing Wei
Nan Wang
Zhangxue Hu
Li Wang
Juan Ma
Shuai Feng
Yue Cai
Xiaopeng Song
Yuan Shi
机构：
[1] Third Military Medical University,Department of Pediatrics, Daping Hospital
[2] Southwest University,Faculty of Psychology
[3] Peking University,College of Engineering
来源：
Neurotoxicity Research | 2016年 / 30卷
关键词：
Resting-state functional magnetic resonance imaging; Amplitude of low-frequency fluctuations; Moderate and late preterm; Primary somatosensory cortex;
D O I：
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学科分类号：
摘要：
Little is known about the frequency features of spontaneous neural activity in the brains of moderate and late preterm (MLPT) newborns. We used resting-state functional magnetic resonance imaging (rs-fMRI) and the amplitude of low-frequency fluctuation (ALFF) method to investigate the frequency properties of spontaneous blood oxygen level-dependent (BOLD) signals in 26 MLPT and 35 term newborns. Two frequency bands, slow-4 (0.027–0.073 Hz) and slow-5 (0.01–0.027 Hz), were analyzed. Our results showed widespread differences in ALFF between the two bands; differences occurred mainly in the primary sensory and motor cortices and to a lesser extent in association cortices and subcortical areas. Compared with term newborns, MLPT newborns showed significantly altered neural activity predominantly in the primary sensory and motor cortices and in the posterior cingulate gyrus/precuneus. In addition, a significant interaction between frequency bands and groups was observed in the primary somatosensory cortex. Intriguingly, these primary sensory and motor regions have been proven to be the major cortical hubs during the neonatal period. Our results revealed the frequency of spontaneous BOLD signal differences between MLPT and term newborns, which contribute to the understanding of regional development of spontaneous brain rhythms of MLPT newborns.
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页码：539 / 551
页数：12
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