A micro-dispenser for long-term storage and controlled release of liquids

被引：0
作者：
Amin Kazemzadeh
Anders Eriksson
Marc Madou
Aman Russom
机构：
[1] KTH Royal Institute of Technology,Division of Nanobiotechnology, Department of Protein Sciences, Science for Life Laboratory
[2] KTH Royal Institute of Technology,School of Engineering Sciences, Mechanics
[3] University of California,Department of Mechanical and Aerospace Engineering
来源：
Nature Communications | / 10卷
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摘要：
The success of lab-on-a-chip systems may depend on a low-cost device that incorporates on-chip storage and fluidic operations. To date many different methods have been developed that cope separately with on-chip storage and fluidic operations e.g., hydrophobic and capillary valves pneumatic pumping and blister storage packages. The blister packages seem difficult to miniaturize and none of the existing liquid handling techniques despite their variety are capable of proportional repeatable dispensing. We report here on an inexpensive robust and scalable micro-dispenser that incorporates long-term storage and aliquoting of reagents on different microfluidics platforms. It provides long-term shelf-life for different liquids enables precise dispensing on lab-on-a-disc platforms and less accurate but proportional dispensing when operated by finger pressure. Based on this technology we introduce a method for automation of blood plasma separation and multi-step bioassay procedures. This micro-dispenser intends to facilitate affordable portable diagnostic devices and accelerate the commercialization of lab-on-a-chip devices.
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