Oxidative stress, inflammation and early cardiovascular damage in children with chronic renal failure

被引：0
作者：
Aydın Ece
Fuat Gürkan
Mehmet Kervancıoğlu
Halil Kocamaz
Ali Güneş
Yıldız Atamer
Şahbettin Selek
Ilyas Yolbas
机构：
[1] Dicle University,Department of Pediatrics, School of Medicine
[2] Dicle University,Department of Biochemistry, School of Medicine
[3] Harran University,Department of Biochemistry, School of Medicine
来源：
Pediatric Nephrology | 2006年 / 21卷
关键词：
Children; Chronic renal failure; Inflammation; Oxidative stress; Left ventricular mass; Intima media thickness;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The relationship between inflammation, oxidant stress and cardiovascular damage in children with chronic renal failure (CRF) has not previously been investigated. The aim of this study was to investigate markers of oxidative stress, inflammation and early cardiovascular abnormalities. Therefore, erythrocyte superoxide dismutase (SOD) and catalase (CAT) activities; blood glutathione (GSH) and serum malondialdehyde (MDA) levels; C-reactive protein (CRP) and proinflammatory cytokines (IL-6, TNF-α,); and left ventricular masses (LVM) and intima media thicknesses (IMT) were measured in children with CRF. A total of 29 children with CRF (19 nondialysis, 10 peritoneal dialysis) were included. The control group consisted of 25 healthy subjects. CRF children had significantly increased IL-6, TNF-α, CRP and MDA concentrations and decreased SOD, CAT and GSH levels compared with controls (P<0.05). Nondialysis and peritoneal dialysis subgroups had similar oxidative stress and inflammation biomarkers (P>0.05). Erythrocyte CAT was positively correlated with CRP, TNF-α, and IL2-R in the study group. Positive correlations were found between cytokine concentrations, CRP and urea/creatinine levels. Significantly increased LVM and IMT values were found in CRF children (P<0.05). In conclusion, increased oxidant stress and inflammation together with early cardiovascular damage were found in CRF children. Further studies with more patients are needed to verify these results.
引用
收藏
页码：545 / 552
页数：7
相关论文
共 199 条
  • [1] Vaziri ND(2003)Oxidative stress and dysregulation of superoxide dismutase and NADPH oxidase in renal insufficiency Kidney Int 63 179-185
  • [2] Dicus M(1994)Reduced erythrocyte defence mechanisms against free radical toxicity in patients with chronic renal failure Nephron 66 76-80
  • [3] Ho ND(2005)Erythrocyte susceptibility to oxidative stress in chronic renal failure patients under different substitutive treatments Artif Organs 29 67-72
  • [4] Boroujerdi-Rad L(2005)IL-10, IL-6, and TNF-α: Central factors in the altered cytokine network of uremia—the good, the bad, and the ugly Kidney Int 67 1226-1233
  • [5] Sindhu RK(1999)Strong association between malnutrition, inflammation, and atherosclerosis in chronic renal failure Kidney Int 55 1899-1911
  • [6] Durak I(2002)C-reactive protein and interleukin-6 levels are related to renal function in predialytic chronic renal failure Nephron 91 594-600
  • [7] Akyol O(2001)Endothelial dysfunction, oxidative stress and risk of cardiovascular events in patients with coronary artery disease Circulation 104 2673-2678
  • [8] Basesme E(2003)Oxidative stress in end-stage renal disease: an emerging threat to patient outcome Nephrol Dial Transplant 18 1272-1280
  • [9] Canbolat O(2002)The elephant in uremia: Oxidant stress as a unifying concept of cardiovascular disease in uremia Kidney Int 62 1524-1538
  • [10] Kavutcu M(2005)Cardiovascular complications in pediatric end-stage renal disease Pediatr Nephrol 20 125-131
12345678910