Comparison of N-Methyl-d-aspartate Receptor Subunit 1 and 4-Hydroxynonenal in the Hippocampus of Natural and Chemical-Induced Aging Accelerated Mice

被引：0
作者：
Sung Min Nam
Tae-Ho Chung
Jong Whi Kim
Hyo Young Jung
Hee Seon Yim
Dae Won Kim
Dae Young Yoo
Hajin Nam
Jung Hoon Choi
In Koo Hwang
Jun-Gyo Suh
Yeo Sung Yoon
机构：
[1] Seoul National University,Department of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute for Veterinary Science
[2] Joongbu University,Department of Animal Science
[3] Kangneung-Wonju National University,Department of Biochemistry and Molecular Biology, Research Institute of Oral Sciences, College of Dentistry
[4] Hallym University,Department of Medical Genetics, College of Medicine
[5] Kangwon National University,Department of Anatomy, College of Veterinary Medicine
来源：
Neurochemical Research | 2014年 / 39卷
关键词：
-Galactose; Natural aging; Hippocampus; -Methyl-; -aspartate receptor subunit 1; 4-Hydroxynonenal;
D O I：
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中图分类号：
学科分类号：
摘要：
In this study, we compared N-methyl-d-aspartate receptor type 1 (NMDAR1) and 4-hydroxynonenal (4-HNE) in the hippocampus of d-galactose (d-gal)-induced and naturally aging models of mice. These markers represent general phenotypes in aging, and they allowed us to examine the possibility of d-gal as a chemical model agent for aging. We observed an age-dependent reduction of NMDAR1 and an increase in 4-HNE in the dentate gyrus, CA1, and CA3 regions of the hippocampus via immunohistochemistry and western blot analyses. In the d-gal-induced chemical aging model, we observed similar changes in NMDAR1 and 4-HNE although the degree of reduction/increase in NMDAR1/4-HNE was not as severe as that in the naturally aged mice. These results suggest that the d-gal-induced aging model is comparable to naturally aged mice and may be useful for studies of the aging hippocampus.
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页码：1702 / 1708
页数：6
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