Role of Epigenetics in Chronic Myeloid Leukemia

被引：0
作者：
Katerina Machova Polakova
Jitka Koblihova
Tomas Stopka
机构：
[1] Institute of Hematology and Blood Transfusion,Institute of Pathophysiology, First Faculty of Medicine
[2] Charles University in Prague,undefined
来源：
Current Hematologic Malignancy Reports | 2013年 / 8卷
关键词：
CML; Epigenetics; microRNA; Tyrosine kinase inhibitors;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The efficacy of therapeutic modalities in chronic myeloid leukemia (CML) depends on both genetic and epigenetic mechanisms. This review focuses on epigenetic mechanisms involved in the pathogenesis of CML and in resistance of tumor cells to tyrosine kinase inhibitors leading to the leukemic clone escape and propagation. Regulatory events at the levels of gene regulation by transcription factors and microRNAs are discussed in the context of CML pathogenesis and therapeutic modalities.
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页码：28 / 36
页数：8
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