Improved Prediction of In Vivo Peroral Absorption from In Vitro Intestinal Permeability Using an Internal Standard to Control for Intra- and Inter-Rat Variability

被引：0
作者：
Martin E. Dowty
Charles R. Dietsch
机构：
[1] Procter and Gamble Pharmaceuticals,Health Care Research Center
来源：
Pharmaceutical Research | 1997年 / 14卷
关键词：
peroral absorption; correlation; intestinal permeability; mass-balance; Ussing chamber; rat;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. To evaluate the use of an in vitrointestinal permeability model to predict rat and human absorption as well as to evaluate the use of an internal standard to control for intra- and inter-rat variability.
引用
收藏
页码：1792 / 1797
页数：5
相关论文
共 53 条
  • [11] Morrison R. A.(1993)undefined Pharm. Res. 10 1123-1129
  • [12] White R. E.(1987)undefined Prog. Drug. Res. 31 273-313
  • [13] Conradi R. A.(1969)undefined Am. J. Med. Sci. 258 80-88
  • [14] Wilkinson K. F.(1980)undefined J. Pharm. Pharmacol. 32 596-599
  • [15] Rush B. D.(1997)undefined Pharm. Res. 14 757-762
  • [16] Hilgers A. R.(undefined)undefined undefined undefined undefined-undefined
  • [17] Ruwart M. J.(undefined)undefined undefined undefined undefined-undefined
  • [18] Burton P. S.(undefined)undefined undefined undefined undefined-undefined
  • [19] Stewart B. H.(undefined)undefined undefined undefined undefined-undefined
  • [20] Chan O. H.(undefined)undefined undefined undefined undefined-undefined
123456