Improved Prediction of In Vivo Peroral Absorption from In Vitro Intestinal Permeability Using an Internal Standard to Control for Intra- and Inter-Rat Variability

被引：0
作者：
Martin E. Dowty
Charles R. Dietsch
机构：
[1] Procter and Gamble Pharmaceuticals,Health Care Research Center
来源：
Pharmaceutical Research | 1997年 / 14卷
关键词：
peroral absorption; correlation; intestinal permeability; mass-balance; Ussing chamber; rat;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. To evaluate the use of an in vitrointestinal permeability model to predict rat and human absorption as well as to evaluate the use of an internal standard to control for intra- and inter-rat variability.
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页码：1792 / 1797
页数：5
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