Prealbumin as a New Marker for Assessment of the Nutritional Status in Patients with Gynecological Malignancies

被引：2
作者：
Mellis M.E.S.H. [1 ]
Rizk M.M.M. [2 ]
Hassan N.E. [1 ]
Mohamed S.A. [1 ]
机构：
[1] Department of Obstetrics and Gynecology, Faculty of Medicine, Alexandria University, Alexandria
[2] Department of Clinical Pathology, Faculty of Medicine, Alexandria University, Alexandria
来源：
Indian Journal of Gynecologic Oncology | 2018年 / 16卷 / 3期
关键词：
Gynecological cancer; Malnutrition; Prealbumin;
D O I：
10.1007/s40944-018-0214-9
中图分类号：
学科分类号：
摘要：
Background: Gynecological malignancies contribute to 10–15% of cancers in women. Malnutrition is a common problem in cancer patients and is a major cause of morbidity and mortality. As a result, it is important to assess every cancer patient’s nutritional status using one or more of the methods that are developed for this purpose. Prealbumin (PAB) is a potential useful marker because its serum concentrations are closely related to early changes in nutritional status. Purpose: To determine the role of PAB in assessment of malnutrition in gynecological cancer patients and to detect the relationship between its serum level and occurrence of treatment-related side effects. Methods: We studied malnutrition prevalence and PAB serum concentrations in 100 gynecological cancer patients. The scored patient-generated subjective global assessment (PG-SGA) was used as the reference method to determine malnutrition. Patients were followed up for development of complications after treatment. Results: According to the PG-SGA reference method, 53% of patients were classified as well nourished and 47% as malnourished (40% moderate malnutrition and 7% severe malnutrition). PAB showed good correlation with the nutritional status assessed by the PG-SGA with good sensitivity (91.49%). Conclusion: We conclude that PAB could represent a feasible and reliable tool in the evaluation of malnutrition in gynecological cancer patients, especially in settings where it is difficult to obtain a more detailed and comprehensive nutritional assessment. © 2018, Association of Gynecologic Oncologists of India.
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