Ononin ameliorates inflammation and cartilage degradation in rat chondrocytes with IL-1β-induced osteoarthritis by downregulating the MAPK and NF-κB pathways

被引:0
作者
Fang Xu
Liang-Jun Zhao
Ting Liao
Zhao-Cong Li
Lei-Lei Wang
Pan-Yu Lin
Rui Jiang
Qing-Jun Wei
机构
[1] The First Affiliated Hospital of Guangxi Medical University,Department of Orthopaedics Trauma and Hand Surgery
[2] Guangxi Medical University,Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases
[3] The First Affiliated Hospital of Guangxi Medical University,Department of Bone and Joint Surgery
[4] Liuzhou Municipal Liutie Central Hospital,Department of Endocrinology
[5] Guangxi Medical University,Department of Toxicology, School of Public Health
来源
BMC Complementary Medicine and Therapies | / 22卷
关键词
Ononin; Osteoarthritis; Chondrocyte; Inflammation; MMP-13; Collagen II; MAPK; NF-κB;
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[11]  
Pan Q(2019)Update on novel pharmacological therapies for osteoarthritis Ther Adv Musculoskelet Dis 11 1759720x19864492-701
[12]  
Mao Z(2021)Osteoarthritis year in review 2020: biology Osteoarthr Cartil 29 143-245
[13]  
Zhang R(2015)Diacerein protects against iodoacetate-induced osteoarthritis in the femorotibial joints of rats J Biomed Res 29 405-730
[14]  
Ma X(2015)Eupatilin Exerts Antinociceptive and Chondroprotective Properties in a Rat Model of Osteoarthritis by Downregulating Oxidative Damage and Catabolic Activity in Chondrocytes PLoS One 10 e0130882-4674
[15]  
Park JS(2009)Protection of PC12 cells against superoxide-induced damage by isoflavonoids from Astragalus mongholicus Biomed Environ Sci 22 50-2196
[16]  
Kim DK(2014)Calycosin-7-O-β-D-glucoside regulates nitric oxide /caveolin-1/matrix metalloproteinases pathway and protects blood-brain barrier integrity in experimental cerebral ischemia-reperfusion injury J Ethnopharmacol 155 692-7010
[17]  
Shin HD(2021)Ononin induces cell apoptosis and reduces inflammation in rheumatoid arthritis fibroblast-like synoviocytes by alleviating MAPK and NF-κB signaling pathways Acta Biochim Pol 68 239-51
[18]  
Lee HJ(2016)Biochanin-a antagonizes the interleukin-1β-induced catabolic inflammation through the modulation of NFκB cellular signaling in primary rat chondrocytes Biochem Biophys Res Commun 477 723-6595
[19]  
Jo HS(2017)Effect of nobiletin on the MAPK/NF-κB signaling pathway in the synovial membrane of rats with arthritis induced by collagen Food Funct 8 4668-1736
[20]  
Jeong JH(2018)Tumor Necrosis Factor Receptor-Associated Factor Regulation of Nuclear Factor κB and Mitogen-Activated Protein Kinase Pathways Front Immunol 9 1849-1491