Critical role of HMGA proteins in cancer cell chemoresistance

被引：0
作者：
Daniela D’Angelo
Paula Mussnich
Claudio Arra
Sabrina Battista
Alfredo Fusco
机构：
[1] Istituto di Endocrinologia ed Oncologia Sperimentale del CNR,Dipartimento di Medicina Molecolare e, Biotecnologie Mediche (DMMBM)
[2] Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale”,undefined
[3] IRCCS,undefined
[4] Università degli Studi di Napoli “Federico II”,undefined
来源：
Journal of Molecular Medicine | 2017年 / 95卷
关键词：
HMGA; Chemoresistance; DNA repair; Apoptosis; miRNAs;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The high-mobility group A (HMGA) proteins are frequently overexpressed in human malignancies and correlate with the presence of metastases and reduced patient survival. Here, we highlight the main studies evidencing a critical role of HMGA in chemoresistance, mainly by activating Akt signaling, impairing p53 activity, and regulating the expression of microRNAs that target genes involved in the susceptibility of cancer cells to antineoplastic agents. Therefore, these studies account for the association of HMGA overexpression with patient poor outcome, indicating the impairment of HMGA as a fascinating perspective for effectively improving cancer therapy.
引用
收藏
页码：353 / 360
页数：7
相关论文
共 484 条
  • [1] Groenendijk F(2014)Drug resistance to targeted therapies: Déjà vu all over again Mol Oncol 8 1067-1083
  • [2] Bernards R(2012)The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance Nat Rev Cancer 12 587-598
  • [3] Bouwman P(2013)DNA damage repair and tolerance: a role in chemotherapeutic drug resistance Br J Biomed Sci 70 31-40
  • [4] Jonkers J(2009)Anti-apoptotic mechanisms of drug resistance in cancer Curr Cancer Drug Targets 9 307-319
  • [5] Salehan MR(2003)The rise of DNA methylation and the importance of chromatin on multidrug resistance in cancer Exp Cell Res 290 177-194
  • [6] Morse HR(2010)Drug resistance, epigenetics, and tumor cell heterogeneity Sci Transl Med 2 28ps19-753
  • [7] Wilson TR(2014)Poised epigenetic states and acquired drug resistance in cancer Nat Rev Cancer 14 747-1096
  • [8] Johnston PG(2005)Cancer chemotherapy and drug metabolism Drug Metab Dispos 33 1083-29
  • [9] Longley DB(2016)Overcoming ABC transporter-mediated multidrug resistance: molecular mechanisms and novel therapeutic drug strategies Drug Resist Updat 27 14-1123
  • [10] Baker EK(2007)Let-7 regulates self renewal and tumorigenicity of breast cancer cells Cell 131 1109-2123
12345678910