A methyl transferase links the circadian clock to the regulation of alternative splicing

被引：0
作者：
Sabrina E. Sanchez
Ezequiel Petrillo
Esteban J. Beckwith
Xu Zhang
Matias L. Rugnone
C. Esteban Hernando
Juan C. Cuevas
Micaela A. Godoy Herz
Ana Depetris-Chauvin
Craig G. Simpson
John W. S. Brown
Pablo D. Cerdán
Justin O. Borevitz
Paloma Mas
M. Fernanda Ceriani
Alberto R. Kornblihtt
Marcelo J. Yanovsky
机构：
[1] IFEVA,Department of Ecology & Evolution
[2] Facultad de Agronomía,Division of Plant Sciences
[3] UBA-CONICET,undefined
[4] IFIBYNE,undefined
[5] FCEyN,undefined
[6] UBA-CONICET,undefined
[7] Fundación Instituto Leloir,undefined
[8] IIBBA-CONICET,undefined
[9] University of Chicago,undefined
[10] Centre for Research in Agricultural Genomics (CRAG),undefined
[11] Consortium CSIC-IRTA-UAB,undefined
[12] Genetics Programme,undefined
[13] SCRI,undefined
[14] Invergowrie,undefined
[15] University of Dundee at SCRI,undefined
来源：
Nature | 2010年 / 468卷
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摘要：
Various biological processes are driven by the day/night cycle to occur at a certain time of day. One way the circadian system exerts these effects is through post-transcriptional regulation. Sanchez et al. show that PRMT5, a protein that transfers methyl groups onto subunits of the spliceosome — the complex that cuts non-protein-coding stretches from pre-RNA — is regulated by the light/dark cycle. This affects alternative splicing of some genes, making them subject to circadian control. This work shows one way by which the environment alters gene expression.
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页码：112 / 116
页数：4
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