The Newcastle 85+ study: Biological, clinical and psychosocial factors associated with healthy ageing: Study protocol

被引：119

作者：

Collerton J. ^{[1
]}

Barrass K. ^{[1
]}

Bond J. ^{[1
]}

Eccles M. ^{[1
]}

Jagger C. ^{[2
]}

James O. ^{[1
]}

Martin-Ruiz C. ^{[1
]}

Robinson L. ^{[1
]}

Von Zglinicki T. ^{[1
]}

Kirkwood T. ^{[1
]}

机构：

[1] Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne

[2] Department of Health Sciences, University of Leicester, Leicester

来源：

BMC Geriatrics | / 7卷 / 1期

基金：

英国医学研究理事会;

关键词：

Oral Health; Telomere Length; Primary Care Trust; Nurse Visit; Health Trajectory;

D O I：

10.1186/1471-2318-7-14

中图分类号：

学科分类号：

摘要：

Background. The UK, like other developed countries, is experiencing a marked change in the age structure of its population characterised by increasing life expectancy and continuing growth in the older fraction of the population. There is remarkably little up-to-date information about the health of the oldest old (over 85 years), demographically the fastest growing section of the population. There is a need, from both a policy and scientific perspective, to describe in detail the health status of this population and the factors that influence individual health trajectories. For a very large proportion of medical conditions, age is the single largest risk factor. Gaining new knowledge about why aged cells and tissues are more vulnerable to pathology is likely to catalyse radical new insights and opportunities to intervene. The aims of the Newcastle 85+ Study are to expose the spectrum of health within an inception cohort of 800 85 year-olds; to examine health trajectories and outcomes as the cohort ages and their associations with underlying biological, medical and social factors; and to advance understanding of the biological nature of ageing. Methods. A cohort of 800 85 year olds from Newcastle and North Tyneside will be recruited at baseline and followed until the last participant has died. Eligible individuals will be all those who turn 85 during the year 2006 (i.e. born in 1921) and who are registered with a Newcastle or North Tyneside general practice. Participants will be visited in their current residence (own home or institution) by a research nurse at baseline, 18 months and 36 months. The assessment protocol entails a detailed multi-dimensional health assessment together with review of general practice medical records. Participants will be flagged with the NHS Central Register to provide details of the date and cause of death. Discussion. The Newcastle 85+ Study will address key questions about health and health-maintenance in the 85+ population, with a particular focus on quantitative assessment of factors underlying variability in health, and on the relationships between health, nutrition and biological markers of the fundamental processes of ageing. © 2007 Collerton et al; licensee BioMed Central Ltd.

引用

共 41 条

[1] Vaupel J.W., Carey J.R., Christensen K., Johnson T.E., Yashin A.I., Holm N.V., Iachine I.A., Kannisto V., Khazaeli A.A., Liedo P., Longo V.D., Zeng Y., Manton K.G., Curtsinger J.W., Biodemographic trajectories of longevity, Science, 280, 5365, pp. 855-860, (1998)
[2] Wilmoth J.R., Demography of longevity: Past, present, and future trends, Experimental Gerontology, 35, pp. 1111-1129, (2000)
[3] Thatcher A.R., The long-term pattern of adult mortality and the highest attained age., J Roy Statist Soc Series a, 162, pp. 5-30, (1999)
[4] Office of Population Censuses and Surveys Monitor
[5] Ons, Key demographics and health indicators, Health Statistics Quarterly, 17, (2003)
[6] Vaupel J., Vaupel J.W., Broken limits to life expectancy, Science, 296, pp. 1029-1031, (2002)
[7] Of Lords Science H., Committee T., Ageing: Scientific Aspects, pp. 10-23, (2005)
[8] Topic Working Group Report to the NHS R&D Strategic Review. Age and Age Associated Disease and Disability, (1999)
[9] Health D., National Service Framework for Older People, (2001)
[10] V Serra Von Zglinicki T., Human fibroblasts in vitro senescence with a donor specific telomere length, FEBS Letters, 516, pp. 71-74, (2002)

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