Conformational analyses of peptides and proteins by vibrational Raman optical activity

被引：0
作者：
Shigeki Yamamoto
机构：
[1] Academy of Sciences of the Czech Republic,Institute of Organic Chemistry and Biochemistry
[2] Kwansei Gakuin University,Department of Chemistry, School of Science and Technology
来源：
Analytical and Bioanalytical Chemistry | 2012年 / 403卷
关键词：
Raman optical activity; ROA; Peptide conformation; Solution structure; Amyloid fibril;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Recent developments of vibrational Raman optical activity (ROA) spectroscopy enabled the detailed analyses of the backbone and side chain conformations of peptides and proteins in solution phases. ROA can be used as a powerful analytical technique for determining not only the structures of conformers, but also their populations even for systems in fast conformational equilibria where NMR spectroscopy is difficult to be applied. ROA enabled the monitoring of the secondary structures of denatured or unfolded proteins, such as an amyloid fibril and its prefibril intermediates.
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页码：2203 / 2212
页数：9
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[1]  
Barron LD(2010)Vibrational optical activity Chem Phys Lett 492 199-213
[2]  
Buckingham AD(1971)Rayleigh and Raman scattering from optically active molecules Mol Phys 20 1111-1119
[3]  
Barron LD(1973)Raman scattering of circularly polarized light by optically active molecules J Am Chem Soc 95 603-605
[4]  
Buckingham AD(1975)Raman circular intensity differential spectroscopy. The spectra of (−)-α-pinene and (+)-α-phenylethylamine J Am Chem Soc 97 5589-5590
[5]  
Barron LD(2007)Absolute configuration of chirally deuterated neopentane Nature 446 526-529
[6]  
Bogaard MP(2005)Raman optical activity: a tool for protein structure analysis Structure 13 1409-1419
[7]  
Buckingham AD(2011)Monitoring the backbone conformation of valinomycin by Raman optical activity Chem Phys Chem 12 1509-1518
[8]  
Hug W(2010)Side chain and flexibility contributions to the Raman optical activity spectra of a model cyclic hexapeptide J Phys Chem A 114 7642-7651
[9]  
Kint S(2010)Formation and structure of the potassium complex of valinomycin in solution studied by Raman optical activity spectroscopy Phys Chem Chem Phys 12 11021-11032
[10]  
Bailey GF(2009)Interpretation of Raman and Raman optical activity spectra of a flexible sugar derivative, the gluconic acid anion J Phys Chem A 113 3594-3601
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