Nuclear remodeling drives age-related cardiac dysfunction

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Nature Aging | 2023年 / 3卷
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We found that aging is accompanied by a reduction in cardiomyocyte nuclear size and increased stiffness, dependent on loss of A-type lamins. Mechanistically, age-dependent nuclear remodeling represses expression of cardiogenic transcription factors that are required for heart contractility. Preserving lamin or transcription factors delays cardiac decline.
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页码：15 / 16
页数：1
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