Biological effects of blood–brain barrier disruption using a focused ultrasound

被引：11

作者：

Han M. ^{[1
]}

Hur Y. ^{[1
]}

Hwang J. ^{[1
]}

Park J. ^{[1
]}

机构：

[1] Medical Device Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, 80 Cheombok-ro, Dong-gu, Daegu

来源：

Biomedical Engineering Letters | 2017年 / 7卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

Biological effects; Blood–brain barrier; Focused ultrasound; Microbubble;

D O I：

10.1007/s13534-017-0025-4

中图分类号：

学科分类号：

摘要：

With focused ultrasound (FUS) and microbubbles, BBB can be transiently disrupted with a localized and non-invasive approach. BBB disruption induced by FUS has made progressions to move forward on delivery of therapeutic agents into a brain in a specific area of brain for better treatment of neurological diseases. In addition to be used as an improvement of drug delivery, BBB disruption has been found to induce biological effects such as a clearance of protein aggregation which cause Alzheimer’s disease, regulation of proteins which facilitate drug uptake, and modulation of neuronal function and neurogenesis. In this review, we discuss overview about the principles of BBB opening with FUS and milestones in these biological effects of FUS-induced BBB disruption. © 2017, Korean Society of Medical and Biological Engineering and Springer.

引用

页码：115 / 120

页数：5

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