Cancer chemopreventive effects of starfish polysaccharide in human breast cancer cells

被引：0
作者：
Kyu-Shik Lee
Jin-Sun Shin
Kyung-Soo Nam
机构：
[1] Dongguk University,Department of Pharmacology, College of Medicine and Intractable Disease Research Center
来源：
Biotechnology and Bioprocess Engineering | 2011年 / 16卷
关键词：
starfish; breast cancer; chemoprevention; polysaccharide; metastasis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We investigated the effect of starfish (Asterina pectinifera) polysaccharide on the progression and metastasis of human breast cancer cells. At a concentration range of 10 ∼ 120 μg/mL the polysaccharide significantly decreased the expression of cyclooxygenase-2 (COX-2) protein induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) and of aromatase mRNA. In a wound healing assay, motility of human MDA-MB-231 breast cancer cells was prevented by the polysaccharide in a dose-dependent manner. These results indicate that starfish polysaccharide can prevent breast cancer progression and metastasis by decreasing prostaglandin E2 and estrogen biosynthesis by COX-2 and aromatase, and by inhibiting cell motility. This report presents information regarding the effectiveness of starfish polysaccharide as a chemopreventive agent against breast cancer.
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页码：987 / 991
页数：4
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