The Human ASCL2 Gene Escaping Genomic Imprinting and Its Expression Pattern

被引：0
作者：
Toshinobu Miyamoto
Shiga Hasuike
Yoshihiro Jinno
Hidenobu Soejima
Kankatsu Yun
Kiyonori Miura
Mutsuo Ishikawa
Norio Niikawa
机构：
[1] Nagasaki University,Department of Human Genetics, School of Medicine
[2] Asahikawa Medical College,Department of Obstetrics and Gynecology
[3] Saga Medical School,Department of Biochemistry
[4] Dunedin School of Medicine,Department of Pathology
[5] University of Otago,Department of Obstetrics and Gynecology, School of Medicine
[6] Nagasaki University,undefined
来源：
Journal of Assisted Reproduction and Genetics | 2002年 / 19卷
关键词：
imprinting; expression; placenta;
D O I：
暂无
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学科分类号：
摘要：
The mouse achaete-scute homolog-2 gene (Ascl2 or Mash2) encodes a transcription factor playing a role in the development of the trophoblast. The Ascl2 is an imprinted gene with maternal expression and assigned to an imprinting gene cluster region (ICR) at a distal region of mouse chromosome 7. We previously isolated a phage clone carrying the human homolog, ASCL2, and mapped it to human chromosome 11p15.5, a human ICR. In the present study, we demonstrate the expression patterns of the human ASCL2 in the fetus at a stage between first and second trimesters and in the placental tissues. In addition, it has been shown that the human ASCL2 gene escapes genomic imprinting.
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页码：240 / 244
页数：4
相关论文
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