A study of the effects of flocalin on respiration and potassium transport of rat-heart and liver mitochondria

被引：0
|
作者：
Khmil N.V. [1 ,4 ]
Gorbacheva O.S. [1 ,2 ]
Strutinskiy R.B. [3 ]
Korobeynikova M.O. [1 ,2 ]
Belosludtseva N.V. [1 ,2 ]
Murzaeva S.V. [2 ]
Mironova G.D. [1 ,2 ]
机构：
[1] Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, 142290, Moscow oblast
[2] Pushchino State University, Pushchino, 142290, Moscow oblast
[3] Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kiev
[4] Karazin Kharkiv National University, Kharkiv
来源：
Biophysics | 2016年 / 61卷 / 6期
关键词：
cardioprotection; flocalin; mitochondria; mitochondrial ATP-dependent potassium channel;
D O I：
10.1134/S0006350916050092
中图分类号：
学科分类号：
摘要：
The effects of the drug flocalin, which possesses cardioprotective properties, on the respiration rates of rat-heart and liver mitochondria in different functional states, the efficiency of oxidative phosphorylation, as well as the transport of potassium ions in these organelles, were studied. It was found that flocalin at concentrations of 7–30 μm stimulated respiration of rat-heart and liver mitochondria in V2 and V4 states in the presence of succinic add as a respiration substrate in a potassium-containing medium. In the absence of potassium ions in the incubation medium, flocalin had no effect on mitochondrial respiration in these states. Studying the functioning of the potassium transport system revealed that flocalin at these concentrations dose-dependently activated the ATP-dependent transport of potassium ions in rat-heart and liver mitochondria. The data we obtained indicate that the cardioprotective effect of flocalin can be associated with activation of the ATP-dependent potassium channel of the inner mitochondrial membrane. © 2016, Pleiades Publishing, Inc.
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页码：888 / 892
页数：4
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