Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion

被引:0
作者
J. Wang
J. Kuusisto
M. Vänttinen
T. Kuulasmaa
J. Lindström
J. Tuomilehto
M. Uusitupa
M. Laakso
机构
[1] University of Kuopio and Kuopio University Hospital,Department of Medicine
[2] University of Kuopio and Kuopio University Hospital,Department of Clinical Nutrition
[3] National Public Health Institute,Department of Epidemiology and Health Promotion
[4] University of Helsinki,Department of Public Health
[5] South Ostrobothnia Central Hospital,undefined
来源
Diabetologia | 2007年 / 50卷
关键词
Genotyping; Impaired fasting glucose; Impaired glucose tolerance; Incidence; Insulin secretion; Insulin sensitivity; Lifestyle intervention; TCF7L2; Type 2 diabetes; Variants;
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学科分类号
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页码:1192 / 1200
页数:8
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  • [1] Grant SF(2006)Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes Nat Genet 38 320-323
  • [2] Thorleifsson G(2006)TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program N Engl J Med 355 241-250
  • [3] Reynisdottir I(2006)Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk Diabetes 55 2640-2644
  • [4] Florez JC(2006)Association of transcription factor 7-like 2 (TCF7L2) variants with type 2 diabetes in a Finnish sample Diabetes 55 2649-2653
  • [5] Jablonski KA(2006)Variant of transcription factor 7-like 2 (TCF7L2) gene and the risk of type 2 diabetes in large cohorts of U.S. women and men Diabetes 55 2645-2648
  • [6] Bayley N(2006)Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals Diabetes 55 2890-2895
  • [7] Groves CJ(2006)Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes Diabetes 55 2903-2908
  • [8] Zeggini E(2006)Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance Diabetes 55 2654-2659
  • [9] Minton J(2006)TCF7L2 variation predicts hyperglycemia incidence in a French general population: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study Diabetes 55 3189-3192
  • [10] Scott LJ(2007)Association of variants of transcription factor 7-like 2 ( Diabetologia 50 59-62