Antiplatelet Agents in the Prevention of Cardiovascular Morbidity and Mortality in Older Patients With Vascular Disease

被引:0
作者
Wilbert S. Aronow
机构
[1] Hebrew Hospital Home,The Department of Geriatrics and Adult Development
[2] Mount Sinai School of Medicine,undefined
来源
Drugs & Aging | 1999年 / 15卷
关键词
Aspirin; Clopidogrel; Ticlopidine; Transient Ischaemic Attack; Peripheral Occlusive Arterial Disease;
D O I
暂无
中图分类号
学科分类号
摘要
Antiplatelet drugs have been demonstrated to reduce the incidence of myocardial infarction (MI), stroke or vascular death in patients with vascular disease. There are no data suggesting that antiplatelet therapy acts differently in older people than in younger people and recommendations based on randomised clinical trials are probably generalisable to older people.
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页码:91 / 101
页数:10
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  • [1] FitzGerald GA(1994)Collaborative overview of randomised trials of antiplatelet therapy: I. Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients BMJ 308 81-106
  • [2] Diener HC(1987)Dipyridamole N Engl J Med 316 1247-57
  • [3] Cunha L(1996)European stroke prevention study 2: dipyridamole and acetylsalicylic acid in the secondary prevention of stroke J Neurol Sci 143 1-13
  • [4] Forbes C(1985)Aspirin, sulfinpyrazone, or both in unstable angina: results of a Canadian multicenter trial N Engl J Med 313 1369-75
  • [5] Cairns JA(1975)The mechanism of the effect of aspirin on human platelets. I. Acetylation of a particulate fraction protein J Clin Invest 56 624-32
  • [6] Gent M(1990)The action of ticlopidine on human platelets: studies on aggregation, secretion, calcium mobilization and membrane glycoproteins Thromb Haemost 64 145-50
  • [7] Singer J(1992)Clopidogrel inhibits the binding of ADPanalogues to the receptor mediating inhibition of platelet adenylate cyclase Arterioscler Thromb 12 430-6
  • [8] Roth GJ(1988)Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17 187 cases of suspected acute myocardial infarction: ISIS-2 Lancet II 349-60
  • [9] Majerus PW(1995)Aspirin in the treatment of acute myocardial infarction in elderly Medicare beneficiaries: patterns of use and outcomes Circulation 92 2841-7
  • [10] Hardisty RM(1996)Marked reduction in long-term cardiac deaths with aspirin after a coronary event J Am Coll Cardiol 28 326-30