Role of IL-6 in spinal cord injury in a mouse model

被引:0
作者
Masaya Nakamura
Seiji Okada
Yoshiaki Toyama
Hideyuki Okano
机构
[1] Keio University School of Medicine,Department of Orthopedic Surgery
[2] Keio University School of Medicine,Department of Physiology
[3] Japan Society and Technology Agency (JST),Core Research for Evolutional Science and Technology (CREST)
来源
Clinical Reviews in Allergy & Immunology | 2005年 / 28卷
关键词
Spinal cord injury; IL-6; glial scar; regeneration;
D O I
暂无
中图分类号
学科分类号
摘要
In recent years, various studies have been conducted toward the goal of achieving regeneration of the central nervous system using neural stem cells. However, various complex factors are involved in the regulation of neural stem cell differentiation, and many unresolved questions remain. It has been reported that after spinal cord injury, the intrinsic neural stem cells do not differentiate into neurons but, rather, into astrocytes, resulting in the formation of glial scars. Based on reports that the expression of interleukin (IL)-6 and the IL-6 receptor (IL-6R) is sharply increased in the acute stages after spinal cord injury and that IL-6 may serve as a factor strongly inducing the differentiation of neural stem cells into astrocytes, we examined the effects of an antibody to IL-6R in cases of spinal cord injury and found that the antibody suppressed secondary injury (caused by inflammatory reactions) and glial scar formation, facilitating functional recovery. This article presents the data from this investigation and discusses the relationship between IL-6 signals and spinal cord injury.
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页码:197 / 203
页数:6
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