Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer’s disease

被引:0
作者
Srikant Rangaraju
Eric B. Dammer
Syed Ali Raza
Priyadharshini Rathakrishnan
Hailian Xiao
Tianwen Gao
Duc M. Duong
Michael W. Pennington
James J. Lah
Nicholas T. Seyfried
Allan I. Levey
机构
[1] Emory University,Department of Neurology
[2] Emory University,Department of Biochemistry
[3] Emory University,undefined
[4] Peptides International,undefined
来源
Molecular Neurodegeneration | / 13卷
关键词
Microglia; Macrophage; Alzheimer’s disease; Network analysis; Kv1.3; Potassium channel; Amyloid; Neuroinflammation;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 485 条
[1]  
Crotti A(2016)Microglial physiology and pathophysiology: insights from genome-wide transcriptional profiling Immunity 44 505-515
[2]  
Ransohoff RM(2014)Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease Nat Rev Neurosci 15 300-312
[3]  
Prinz M(2017)Microglia in Alzheimer’s disease J Clin Invest 127 3240-3249
[4]  
Priller J(2010)Microglia in neurodegenerative disease Nat Rev Neurol 6 193-201
[5]  
Sarlus H(2016)Microglial genes regulating neuroinflammation in the progression of Alzheimer’s disease Curr Opin Neurobiol 36 74-81
[6]  
Heneka MT(2016)TREM2 variants: new keys to decipher Alzheimer disease pathogenesis Nat Rev Neurosci 17 201-207
[7]  
Perry VH(2013)Variant of TREM2 associated with the risk of Alzheimer’s disease N Engl J Med 368 107-116
[8]  
Nicoll JA(2013)Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer’s disease Cell 153 707-720
[9]  
Holmes C(2017)A unique microglia type associated with restricting development of Alzheimer’s disease Cell 169 1276-1290
[10]  
Villegas-Llerena C(2018)Diverse brain myeloid expression profiles reveal distinct microglial activation states and aspects of Alzheimer’s disease not evident in mouse models Cell Rep 22 832-847