Cervical pregnancy treated with transvaginal ultrasound-guided intra-amniotic instillation of methotrexate

被引:19
作者
Hassiakos D. [1 ]
Bakas P. [1 ]
Creatsas G. [1 ]
机构
[1] 2nd Dept. of Obstet. and Gynecology, Aretaieio Hospital, University of Athens, 11522 Athens
关键词
Cervical pregnancy; Ectopic pregnancy; Heterotopic pregnancy; Methotrexate;
D O I
10.1007/s00404-003-0567-9
中图分类号
学科分类号
摘要
Aim: Aim of the study was to investigate the efficacy of single transvaginal ultrasound-guided intraamniotic installation of methotrexate in the management of cervical pregnancy with concurrent review of the literature. Materials and methods: Six patients with cervical pregnancy are included in the study. All patients were treated with single transvaginal ultrasound-guided intraamniotic installation of 70 mg of methotrexate plus folic acid p.o. The main presenting symptoms were mild to moderate vaginal bleeding and lower abdominal cramp-like pain, resembling the clinical presentation of a threatened abortion. The typical ultrasound findings were the absence of intrauterine gestational sac and the detection of a gestational sac within the cervical canal, invading the anterior or the posterior wall of the cervix and normal appearance of the adnexa, bilaterally. The hourglass-shaped cervix was not characteristic at 5 weeks of gestation but it was at 8 weeks of gestation. Discussion: Ultrasound-guided intraamniotic installation of methotrexate in the management of cervical pregnancy appears to be an effective and safe method but the choice of the method should be depended on the gestational age of cervical pregnancy, the presence of active bleeding or not and its severity, the desire for preservation of future fertility, the presence of coexisting valuable intrauterine pregnancy and the experience of the physician in charge. © Springer-Verlag 2004.
引用
收藏
页码:69 / 72
页数:3
相关论文
共 16 条
[1]  
Chen D., Kligman I., Rosenwaks Z., Heterotopic cervical pregnancy successfully treated with transvaginal ultrasound guided aspiration and cervical-stay sutures, Fertil Steril, 75, pp. 1030-1033, (2001)
[2]  
Creinin M., Feldstein V., Conservative management options for cervical pregnancy: Case reports and literature review, Int J Fertil, 40, pp. 175-186, (1995)
[3]  
Frates M.C., Benson C.B., Doubilet P.M., Cervical ectopic pregnancy: Results of conservative treatment, Radiology, 191, pp. 773-775, (1994)
[4]  
Fylstra D.L., Coffey M.D., Treatment of cervical pregnancy with circlage, curettage and balloon tamponade. A report of three cases, J Reprod Med, 46, pp. 71-74, (2001)
[5]  
Ginsburg E., Fox J., Frates M., Hornstein M., Rein M., Friedman A., Early diagnosis and treatment of cervical pregnancy in an in vitro fertilization program, Fertil Steril, 61, pp. 966-999, (1994)
[6]  
Has R., Ermis H., Ibrahinoglu L., Yildirim A., A 22 week cervical pregnancy, Gynecol Obstet Invest, 50, pp. 139-141, (2000)
[7]  
Has R., Balci N.C., Ibrahinoglu L., Rozanes I., Topuz S., Uterine artery embolization in a 10 week cervical pregnancy with coexisting fibroids, Int J Gynecol Obstet, 72, pp. 253-258, (2001)
[8]  
Hung T.H., Chiu T.H., Hsu J.J., Chen K.C., Hsieh T.T., Sonographic evolution of a living cervical pregnancy treated with intraamniotic instillation of methotrexate, J Ultrasound Med, 16, pp. 843-847, (1997)
[9]  
Jung S.E., Byun J.Y., Lee J.M., Choi B.G., Hahn S.T., Characteristic MR findings of cervical pregnancy, J Magn Reson Imaging, 13, pp. 918-922, (2001)
[10]  
Kuppuswami N., Vindekilde J., Sethi C.M., Diagnosis and treatment of cervical pregnancy, Obstet Gynecol, 61, pp. 651-653, (1983)