Blockade of Different Subtypes of α1-Adrenoceptors Produces Opposite Effect on Heart Chronotropy in Newborn Rats

被引：0
作者：
N. I. Ziyatdinova
R. E. Dementieva
L. I. Fashutdinov
T. L. Zefirov
机构：
[1] Kazan (Privolzhskii) Federal University,Department of Anatomy, Physiology, and Human Health Protection
来源：
Bulletin of Experimental Biology and Medicine | 2012年 / 154卷
关键词：
heart; α; -adrenoceptor; sympathetic regulation; rat; ontogeny;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We compared the effects of blockade of α1A-, α1В-, and α1D-subtypes of α1-adrenoceptors on the cardiac rhythm in newborn rats. Different responses of the heart were observed after blockade of several subtypes of α1-adrenoceptors. Administration of WB 4101, a selective blocker of α1A-adrenoceptors, increased heart rate, while blockade of α1AD-adrenoceptors with BMY 7378 decelerated of heart rhythm. Blockade of α1В-adrenoceptors with chloroethylclonidine produced no significant effects on heart chronotropy.
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页码：184 / 185
页数：1
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