The receptor for advanced glycation end products and acute lung injury/acute respiratory distress syndrome

被引：0
作者：
Weidun Alan Guo
Paul R. Knight
Krishnan Raghavendran
机构：
[1] State University of New York at Buffalo,Department of Surgery
[2] State University of New York at Buffalo,Department of Anesthesiology
[3] University of Michigan Health Systems,Department of Surgery
来源：
Intensive Care Medicine | 2012年 / 38卷
关键词：
Receptor for advanced glycation end products; Acute lung injury; Acute respiratory distress syndrome; Damage-associated molecular patterns;
D O I：
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中图分类号：
学科分类号：
摘要：
The receptor for advanced glycation end products (RAGE) is a pattern-recognition receptor and evolutionary member of the immunoglobulin superfamily that is involved in the host response to infection, injury, and inflammation. It exists in two forms: membrane-bound and soluble forms (sRAGE). RAGE recognizes a variety of ligands and, via a receptor-driven signaling cascade, activates the transcription factor NF-κB, leading to the expression of proinflammatory cytokines. The soluble form, sRAGE, is a decoy receptor and competitively inhibits membrane RAGE activation. RAGE is constitutively expressed abundantly in the lung under basal conditions. This expression is enhanced during inflammatory states such as with acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). This review summarizes the characteristics of RAGE, RAGE isoforms, RAGE ligands, and signaling pathways in the pathogenesis of ALI and ARDS. Additionally, the review explores the potential of RAGE as an important therapeutic target in ALI/ARDS.
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页码：1588 / 1598
页数：10
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