Systemic onset juvenile idiopathic arthritis

被引：2

作者：

Frosch, M. ^{[1
]}

Holzinger, D. ^{[1
,2
]}

Roth, J. ^{[2
]}

机构：

[1] Univ Klinikum Munster, Klin & Poliklin Kinder & Jugendmed, D-48149 Munster, Germany

[2] Univ Klinikum Munster, Inst Immunol, D-48149 Munster, Germany

来源：

MONATSSCHRIFT KINDERHEILKUNDE | 2012年 / 160卷 / 03期

关键词：

Juvenile idiopathic arthritis; Systemic JIA; Interleukin-1; S100; proteins; Cytokine blockade; MACROPHAGE ACTIVATION SYNDROME; GENE-EXPRESSION PROFILES; RHEUMATOID-ARTHRITIS; PERIPHERAL-BLOOD; METHOTREXATE; CYTOKINE; INTERLEUKIN-18; ASSOCIATIONS; PATHOGENESIS; CHILDREN;

D O I：

10.1007/s00112-011-2545-9

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Systemic juvenile idiopathic arthritis (SJIA) is characterized by fever, a transient rash and arthritis. The disease often starts with fever of unknown origin. A chronic active course of disease is associated with high morbidity: in particular, joint destruction and secondary growth retardation are common complications. The activation of the innate immune system is the underlying pathogenetic process and is characterized by stimulated phagocytes which secrete interleukin-1 (IL-1), IL-6 and S100 proteins. The latter can be used for differential diagnosis in the situation of fever of unknown origin. In a severe course of SJIA that is resistant to treatment with steroids, methotrexate and TNF blockade, new therapeutic approaches with antagonists or antibodies against IL-1 and IL-6 have been established. Hopefully, these treatment regimens will be associated with a favourable prognosis of SJIA for a larger patient population.

引用

页码：217 / +

页数：6

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