PET Imaging Study of S1PR1 Expression in a Rat Model of Multiple Sclerosis

[1] Mahad DH(2015)Pathological mechanisms in progressive multiple sclerosis Lancet Neurol 14 183-193

[2] Trapp BD(2015)Multiple sclerosis—a quiet revolution Nat Rev Neurol 11 134-142

[3] Lassmann H(2009)Chemical modulators of sphingosine-1-phosphate receptors as barrier-oriented therapeutic molecules Nat Rev Drug Discov 8 297-307

[4] Ransohoff RM(2010)A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis N Engl J Med 362 387-401

[5] Hafler DA(2012)Fingolimod for multiple sclerosis N Engl J Med 366 339-347

[6] Lucchinetti CF(2011)FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation Proc Natl Acad Sci U S A 108 751-756

[7] Marsolais D(2012)A sphingosine-1-phosphate receptor 1-directed agonist reduces central nervous system inflammation in a plasmacytoid dendritic cell-dependent manner J Immunol 189 3700-3706

[8] Rosen H(2012)S1P Mol Pharmacol 81 166-174

[9] Kappos L(2010) receptor modulation with cyclical recovery from lymphopenia ameliorates mouse model of multiple sclerosis Glia 58 1465-1476

[10] Radue EW(2013)Sphingosine 1-phosphate receptor 1 and 3 are upregulated in multiple sclerosis lesions Nat Immunol 14 1166-1172

[1] Mahad DH(2015)Pathological mechanisms in progressive multiple sclerosis Lancet Neurol 14 183-193

[2] Trapp BD(2015)Multiple sclerosis—a quiet revolution Nat Rev Neurol 11 134-142

[3] Lassmann H(2009)Chemical modulators of sphingosine-1-phosphate receptors as barrier-oriented therapeutic molecules Nat Rev Drug Discov 8 297-307

[4] Ransohoff RM(2010)A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis N Engl J Med 362 387-401

[5] Hafler DA(2012)Fingolimod for multiple sclerosis N Engl J Med 366 339-347

[6] Lucchinetti CF(2011)FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation Proc Natl Acad Sci U S A 108 751-756

[7] Marsolais D(2012)A sphingosine-1-phosphate receptor 1-directed agonist reduces central nervous system inflammation in a plasmacytoid dendritic cell-dependent manner J Immunol 189 3700-3706

[8] Rosen H(2012)S1P Mol Pharmacol 81 166-174

[9] Kappos L(2010) receptor modulation with cyclical recovery from lymphopenia ameliorates mouse model of multiple sclerosis Glia 58 1465-1476

[10] Radue EW(2013)Sphingosine 1-phosphate receptor 1 and 3 are upregulated in multiple sclerosis lesions Nat Immunol 14 1166-1172