Mapping higher order structure of chromatin domains

被引：0

作者：

Celso A Espinoza

Bing Ren

机构：

[1] Celso A. Espinoza and Bing Ren are at the Ludwig Institute for Cancer Research at the University of California,

[2] San Diego,undefined

[3] La Jolla,undefined

[4] California,undefined

[5] USA.,undefined

来源：

Nature Genetics | 2011年 / 43卷

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摘要：

Large-scale mapping of chromatin state and transcription factor binding have uncovered many broad chromatin domains along linear genomic DNA, but it is unclear how these functional domains are organized in three-dimensional nuclear space. A new study now shows that many domains exist as loops connected by CCTC-binding factor (CTCF), providing new insights into the higher-order structure of chromatin organization in the nucleus.

引用

页码：615 / 616

页数：1

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