A novel machine learning-based approach for the computational functional assessment of pharmacogenomic variants

被引:0
作者
Maria-Theodora Pandi
Maria Koromina
Iordanis Tsafaridis
Sotirios Patsilinakos
Evangelos Christoforou
Peter J. van der Spek
George P. Patrinos
机构
[1] Erasmus University Medical Center,Laboratory of Pharmacogenomics and Individualized Therapy, Department of Pharmacy, School of Health Sciences
[2] Faculty of Medicine and Health Sciences,Zayed Center of Health Sciences
[3] Department of Pathology,Department of Pathology, College of Medicine and Health Sciences
[4] Bioinformatics Unit,undefined
[5] University of Patras,undefined
[6] The Golden Helix Foundation,undefined
[7] Katharsis Technologies Inc.,undefined
[8] Konstantopouleion General Hospital,undefined
[9] United Arab Emirates University,undefined
[10] United Arab Emirates University,undefined
来源
Human Genomics | / 15卷
关键词
Machine learning; Computational approaches; Functional prediction; Pharmacogenomic variants;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 263 条
[1]  
Zhou ZW(2015)Clinical association between pharmacogenomics and adverse drug reactions Drugs. 75 589-631
[2]  
Chen XW(2017)Pharmacogenomic biomarkers for improved drug therapy-recent progress and future developments AAPS J. 20 4-577
[3]  
Sneed KB(2017)The challenges of implementing pharmacogenomic testing in the clinic Expert Rev Pharmacoecon Outcomes Res. 17 567-1234
[4]  
Yang YX(2014)Personalized pharmacogenomics profiling using whole-genome sequencing Pharmacogenomics. 15 1223-210
[5]  
Zhang X(2015)Whole genome sequencing in pharmacogenomics Front Pharmacol. 6 61-350
[6]  
He ZX(2019)Integrating next-generation sequencing in the clinical pharmacogenomics workflow Front Pharmacol. 10 384-104
[7]  
Lauschke VM(2015)Pharmacogenomic information in drug labels: European Medicines Agency perspective Pharmacogenomics J. 15 201-594
[8]  
Milani L(2015)Pharmacogenomics in the clinic Nature. 526 343-29
[9]  
Ingelman-Sundberg M(2012)Evolution and functional impact of rare coding variation from deep sequencing of HUMAN Exomes Science. 337 64-559
[10]  
Moyer AM(2012)An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people Science. 337 100-446