Relationships Between Resistance and Virulence in Burkholderia pseudomallei

被引：0
作者：
Schnetterle M. [1 ]
Koch L. [1 ]
Gorgé O. [1 ]
Valade E. [1 ,2 ]
Bolla J.-M. [3 ]
Biot F. [1 ]
Neulat-Ripoll F. [1 ]
机构：
[1] Unité de Bactériologie UMR_MD1, Institut de Recherche Biomédicale des Armées (IRBA), 1 place du Général Valérie André BP73, Brétigny-sur-Orge
[2] Ecole du Val de Grâce, Paris
[3] TMCD2 UMR_MD1, Aix Marseille Université, Marseille
来源：
Current Tropical Medicine Reports | 2017年 / 4卷 / 3期
关键词：
Antibiotic resistance; Burkholderia pseudomallei; Melioidosis; Virulence;
D O I：
10.1007/s40475-017-0119-1
中图分类号：
学科分类号：
摘要：
Purpose of Review: Aroused by the capacity of bacteria to develop antimicrobial resistance which allows them to persist in patient under antibiotic treatment, and their adaptation to host defenses by modifying their virulence, we review the relationship between antibiotic resistance and virulence in Burkholderia pseudomallei. Recent Finding: Few studies focused on both antibiotic resistance and virulence. The relationship between these two mechanisms is very complex. Main resistance mechanisms such as efflux, biofilm, morphological changes or persistence are linked to virulence but results are still controversial. Recent clinical reports seem to indicate that reductive evolution is involved for balancing antibiotic resistance and virulence in chronic melioidosis cases. Summary: The relation of virulence and resistance should be more considered to better understand the resistance, persistence, and pathogenicity of B. pseudomallei. Focusing on these two mechanisms, it will be possible to improve therapeutic options against this important emerging disease and avoid therapy failures or relapses for B. pseudomallei. © 2017, Springer International Publishing AG.
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页码：127 / 135
页数：8
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