Hemodynamic responses to metaboreflex activation: insights from spinal cord-injured humans

被引：0
作者：
Antonio Crisafulli
Raffaele Milia
Stefano Vitelli
Manuela Caddeo
Filippo Tocco
Franco Melis
Alberto Concu
机构：
[1] University of Cagliari,Section of Human Physiology, Department of Science Applied to Biological Systems
来源：
European Journal of Applied Physiology | 2009年 / 106卷
关键词：
Blood pressure; Cardiovascular; Exercise; Stroke volume;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
This investigation was conducted to study the hemodynamic consequences of spinal cord injury (SCI) during post-exercise muscle metaboreflex activation in SCI subjects. The hemodynamic response to metaboreflex recruitment was assessed in ten SCI patients and nine healthy controls (CTL) by means of impedance cardiography. The main results were (1) the metaboreflex-induced blood pressure rise was blunted in SCI subjects compared with normals, (2) the CTL group achieved the blood pressure response via cardiac output increase, while the SCI subjects could not use this mechanism, (3) the CTL group was able to enhance stroke volume and ventricular filling rate in response to the metaboreflex, whereas the SCI group could not. It was concluded that in healthy individuals, the hemodynamic response to the metaboreflex is an integrated phenomenon that depends mainly on a flow-mediated mechanism, whereas in SCI individuals the reduced venous return impairs this mechanism.
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页码：525 / 533
页数：8
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