Management of arterial hypertension

被引:27
作者
Wermelt, J. A. [1 ]
Schunkert, H. [1 ]
机构
[1] Tech Univ Munich, Klin Herz & Kreislauferkrankungen, Deutsch Herzzentrum Munchen, Lazarettstr 36, D-80636 Munich, Germany
关键词
Arterial hypertension; Diagnosis; Target blood pressure; Antihypertensive agents; Non-pharmacological treatment; SYSTOLIC BLOOD-PRESSURE; RISK-FACTORS; METAANALYSIS; MORTALITY; DISEASE; HOME;
D O I
10.1007/s00059-017-4574-1
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Arterial hypertension has a high prevalence and is a major risk factor for the development of cardiovascular diseases. It is a major contributor to worldwide morbidity and mortality and hence poses a huge socioeconomic burden. Despite great progress in perception, diagnosis and treatment of hypertension, blood pressure control is inadequate in less than half of the hypertensive patients (<140/90 mm Hg). The diagnosis of arterial hypertension starts in most patients with the conventional office blood pressure measurement. Out-of-office blood pressure measurement is an important adjunct, especially to unmask white-coat hypertension. To reach the right target blood pressure many effective antihypertensive drugs are available. By how much the blood pressure should be lowered is currently a matter of controversy. The 2013 European and the identical German national guidelines recommend a target blood pressure of <140/90 mm Hg for most patients. The recent SPRINT study revealed that some patients may benefit from an even lower blood pressure. This CME-article summarizes recent developments in the management of arterial hypertension and provides tips for daily practice based on these aims.
引用
收藏
页码:515 / 526
页数:12
相关论文
共 27 条
[11]   Unattended Blood Pressure Measurements in the Systolic Blood Pressure Intervention Trial Implications for Entry and Achieved Blood Pressure Values Compared With Other Trials [J].
Kjeldsen, Sverre E. ;
Lund-Johansen, Per ;
Nilsson, Peter M. ;
Mancia, Giuseppe .
HYPERTENSION, 2016, 67 (05) :808-812
[12]  
Lewington S, 2002, LANCET, V360, P1903, DOI 10.1016/S0140-6736(02)11911-8
[13]   A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010 [J].
Lim, Stephen S. ;
Vos, Theo ;
Flaxman, Abraham D. ;
Danaei, Goodarz ;
Shibuya, Kenji ;
Adair-Rohani, Heather ;
Amann, Markus ;
Anderson, H. Ross ;
Andrews, Kathryn G. ;
Aryee, Martin ;
Atkinson, Charles ;
Bacchus, Loraine J. ;
Bahalim, Adil N. ;
Balakrishnan, Kalpana ;
Balmes, John ;
Barker-Collo, Suzanne ;
Baxter, Amanda ;
Bell, Michelle L. ;
Blore, Jed D. ;
Blyth, Fiona ;
Bonner, Carissa ;
Borges, Guilherme ;
Bourne, Rupert ;
Boussinesq, Michel ;
Brauer, Michael ;
Brooks, Peter ;
Bruce, Nigel G. ;
Brunekreef, Bert ;
Bryan-Hancock, Claire ;
Bucello, Chiara ;
Buchbinder, Rachelle ;
Bull, Fiona ;
Burnett, Richard T. ;
Byers, Tim E. ;
Calabria, Bianca ;
Carapetis, Jonathan ;
Carnahan, Emily ;
Chafe, Zoe ;
Charlson, Fiona ;
Chen, Honglei ;
Chen, Jian Shen ;
Cheng, Andrew Tai-Ann ;
Child, Jennifer Christine ;
Cohen, Aaron ;
Colson, K. Ellicott ;
Cowie, Benjamin C. ;
Darby, Sarah ;
Darling, Susan ;
Davis, Adrian ;
Degenhardt, Louisa .
LANCET, 2012, 380 (9859) :2224-2260
[14]   Blood-Pressure Lowering in Intermediate-Risk Persons without Cardiovascular Disease [J].
Lonn, Eva M. ;
Bosch, Jackie ;
Lopez-Jaramillo, Patricio ;
Zhu, Jun ;
Liu, Lisheng ;
Pais, Prem ;
Diaz, Rafael ;
Xavier, Denis ;
Sliwa, Karen ;
Dans, Antonio ;
Avezum, Alvaro ;
Piegas, Leopoldo S. ;
Keltai, Katalin ;
Keltai, Matyas ;
Chazova, Irina ;
Peters, Ron J. G. ;
Held, Claes ;
Yusoff, Khalid ;
Lewis, Basil S. ;
Jansky, Petr ;
Parkhomenko, Alexander ;
Khunti, Kamlesh ;
Toff, William D. ;
Reid, Christopher M. ;
Varigos, John ;
Leiter, Lawrence A. ;
Molina, Dora I. ;
McKelvie, Robert ;
Pogue, Janice ;
Wilkinson, Joanne ;
Jung, Hyejung ;
Dagenais, Gilles ;
Yusuf, Salim .
NEW ENGLAND JOURNAL OF MEDICINE, 2016, 374 (21) :2009-2020
[15]  
Mancia G, 2007, EUR HEART J, V28, P1462, DOI [10.1093/eurheartj/ehm236, 10.1093/eurheartj/eht151]
[16]  
Middeke M, 2015, INTERNIST, V56, P230, DOI 10.1007/s00108-014-3570-2
[17]   Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1.25 million people [J].
Rapsomaniki, Eleni ;
Timmis, Adam ;
George, Julie ;
Pujades-Rodriguez, Mar ;
Shah, Anoop D. ;
Denaxas, Spiros ;
White, Ian R. ;
Caulfield, Mark J. ;
Deanfield, John E. ;
Smeeth, Liam ;
Williams, Bryan ;
Hingorani, Aroon ;
Hemingway, Harry .
LANCET, 2014, 383 (9932) :1899-1911
[18]   Polymorphism of the angiotensin-converting enzyme gene and cardiovascular disease [J].
Schunkert, H .
JOURNAL OF MOLECULAR MEDICINE-JMM, 1997, 75 (11-12) :867-875
[19]   A Randomized Trial of Intensive versus Standard Blood-Pressure Control [J].
Wright, Jackson T., Jr. ;
Williamson, Jeff D. ;
Whelton, Paul K. ;
Snyder, Joni K. ;
Sink, Kaycee M. ;
Rocco, Michael V. ;
Reboussin, David M. ;
Rahman, Mahboob ;
Oparil, Suzanne ;
Lewis, Cora E. ;
Kimmel, Paul L. ;
Johnson, Karen C. ;
Goff, David C., Jr. ;
Fine, Lawrence J. ;
Cutler, Jeffrey A. ;
Cushman, William C. ;
Cheung, Alfred K. ;
Ambrosius, Walter T. .
NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (22) :2103-2116
[20]  
Steffen HM, 2016, MMW-FORTSCH MEDIZIN, V17, P158, DOI DOI 10.1007/s15006-016-8781-0