Modulation of the unfolded protein response impedes tumor cell adaptation to proteotoxic stress: a PERK for hepatocellular carcinoma therapy

被引：0
|
作者：
Yves-Paul Vandewynckel
Debby Laukens
Eliene Bogaerts
Annelies Paridaens
Anja Van den Bussche
Xavier Verhelst
Christophe Van Steenkiste
Benedicte Descamps
Chris Vanhove
Louis Libbrecht
Riet De Rycke
Bart N. Lambrecht
Anja Geerts
Sophie Janssens
Hans Van Vlierberghe
机构：
[1] Ghent University,Department of Hepatology and Gastroenterology
[2] Ghent University,Infinity Imaging Lab
[3] Ghent University,GROUP
[4] Ghent University,ID Consortium, Ghent University Hospital
[5] VIB Inflammation Research Center,Department of Pathology
[6] Ghent University,Unit Immunoregulation and Mucosal Immunology
来源：
Hepatology International | 2015年 / 9卷
关键词：
Liver neoplasm; Endoplasmic reticulum; Stress; HepG2 cells; PERK kinase; Inositol-requiring enzyme-1;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：93 / 104
页数：11
相关论文
共 50 条
  • [21] Cancer nanotechnology: Enhancing tumor cell response to chemotherapy for hepatocellular carcinoma therapy
    Yongbing Sun
    Wen Ma
    Yuanyuan Yang
    Mengxue He
    Aimin Li
    Lei Bai
    Bin Yu
    Zhiqiang Yu
    Asian Journal of Pharmaceutical Sciences, 2019, 14 (06) : 581 - 594
  • [22] Cancer nanotechnology: Enhancing tumor cell response to chemotherapy for hepatocellular carcinoma therapy
    Sun, Yongbing
    Ma, Wen
    Yang, Yuanyuan
    He, Mengxue
    Li, Aimin
    Bai, Lei
    Yu, Bin
    Yu, Zhiqiang
    ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2019, 14 (06) : 581 - 594
  • [23] Prognostic Role of Unfolded Protein Response-Related Genes in Hepatocellular Carcinoma
    Zhang, Shuqiao
    Li, Xinyu
    Zheng, Yilu
    Hu, Hao
    Liu, Jiahui
    Zhang, Shijun
    Tang, Chunzhi
    Mo, Zhuomao
    Kuang, Weihong
    CURRENT PROTEIN & PEPTIDE SCIENCE, 2023, 24 (08) : 666 - 683
  • [24] The Unfolded Protein Response Score Is Associated with Cancer Progression and Survival in Hepatocellular Carcinoma
    Patel, Ankit
    Takabe, Kazuaki
    JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 2021, 233 (05) : S256 - S257
  • [25] The Unfolded Protein Response Is Associated with Cancer Proliferation and Worse Survival in Hepatocellular Carcinoma
    Patel, Ankit
    Oshi, Masanori
    Yan, Li
    Matsuyama, Ryusei
    Endo, Itaru
    Takabe, Kazuaki
    CANCERS, 2021, 13 (17)
  • [26] Alterations of the microenvironment of hepatocellular carcinoma in different unfolded protein response activity states
    Wang, Yao
    Zhu, Xiao Fei
    Gu, Wan Jian
    Zhang, Gui Hong
    DISCOVER ONCOLOGY, 2025, 16 (01)
  • [27] The PERK Arm of the Unfolded Protein Response Regulates Mitochondrial Morphology during Acute Endoplasmic Reticulum Stress
    Lebeau, Justine
    Saunders, Jaclyn M.
    Moraes, Vivian W. R.
    Madhavan, Aparajita
    Madrazo, Nicole
    Anthony, Mary C.
    Wiseman, R. Luke
    CELL REPORTS, 2018, 22 (11): : 2827 - 2836
  • [28] Neuroprotective modulation of the unfolded protein response in Marinesco-Sj?gren syndrome: PERK signaling inhibition and beyond
    Elena Restelli
    Antonio Masone
    Michele Sallese
    Roberto Chiesa
    Neural Regeneration Research, 2019, 14 (01) : 62 - 64
  • [29] PERK-Mediated Unfolded Protein Response Activation and Oxidative Stress in PARK20 Fibroblasts
    Amodio, Giuseppina
    Moltedo, Ornella
    Fasano, Dominga
    Zerillo, Lucrezia
    Oliveti, Marco
    Di Pietro, Paola
    Faraonio, Raffaella
    Barone, Paolo
    Pellecchia, Maria Teresa
    De Rose, Anna
    De Michele, Giuseppe
    Polishchuk, Elena
    Polishchuk, Roman
    Bonifati, Vincenzo
    Nitsch, Lucio
    Pierantoni, Giovanna Maria
    Renna, Maurizio
    Criscuolo, Chiara
    Paladino, Simona
    Remondelli, Paolo
    FRONTIERS IN NEUROSCIENCE, 2019, 13
  • [30] The unfolded protein response relieves stress in tumor cells by stimulating angiogenesis
    Wang, Yugang
    Ning, Yu
    Alam, Goleeta
    Visioli, Fernanda
    Nor, Jacques E.
    Polverini, Peter J.
    CANCER RESEARCH, 2011, 71
12345