The sero-epidemiology of human papillomavirus among Caucasian transplant recipients in the UK

被引：9

作者：

Casabonne D. ^{[1
]}

Waterboer T. ^{[2
]}

Michael K.M. ^{[2
]}

Pawlita M. ^{[2
]}

Lally A. ^{[3
]}

Mitchell L. ^{[4
]}

Imko-Walczuk B. ^{[5
]}

Wojnarowska F. ^{[3
]}

Newton R. ^{[6
]}

Proby C. ^{[7
]}

Harwood C. ^{[4
]}

机构：

[1] Cancer Epidemiology Unit, Richard Doll Building, University of Oxford, Headington, Oxford, OX3 7LF, Old Road Campus, Roosevelt Drive

[2] Infection and Cancer Program (F020), German Cancer Research Center (DKFZ), 69120 Heidelberg

[3] Department of Dermatology, Churchill Hospital, Oxford Radcliffe Hospitals, Oxford

[4] Centre for Cutaneous Research, Institute of Cell and Molecular Science, University of London

[5] Clinical Department of Plastic Surgery, Medical Academy of Gdask, 80-952 Gdask, Poland

[6] Epidemiology and Genetics Unit, Department of Health Sciences, University of York, Heslington, York

[7] Division of Surgery and Oncology, Ninewells Hospital and Medical School, University of Dundee

来源：

Infectious Agents and Cancer | / 4卷 / 1期

关键词：

Genital Wart; Organ Transplant Recipient; Cutaneous Squamous Cell Carcinoma; Alpha Type; Epidermodysplasia Verruciformis;

D O I：

10.1186/1750-9378-4-13

中图分类号：

学科分类号：

摘要：

Background. Despite intensive study of high-risk mucosal human papillomaviruses (HPV), little is known of the epidemiology of cutaneous HPV. As part of a study of cutaneous squamous cell carcinoma and HPV among organ transplant recipients (OTR) from London and Oxford, we investigated the seroprevalence and risk factors for 34 HPV types (detected using Luminex technology) among 425 Caucasian OTR without skin cancer. Results. Overall, 86% of participants were seropositive to at least one HPV: 41% to mucosal alpha types, 33% to cutaneous alpha types, 57% to alpha types, 56% to beta, 47% to gamma types and 45% to other types (nu, mu, HPV101 and 103). In both centres, the most common types were HPV6 (33% and 26% for London and Oxford respectively), HPV8 (24% and 18%), HPV15 (26% and 29%), HPV17 (25% and 21%), HPV38 (23% and 21%), HPV49 (19% and 21%), HPV4 (27% and 23%), HPV65 (30% and 25%), HPV95 (22% and 20%), HPV1 (33% and 24%) and HPV63 (28% and 17%). The seroprevalence of 8 HPV types differed significantly (P < 0.05) between London and Oxford. Those individuals seropositive to multiple types of one genus were more likely to be seroreactive to multiple types of another genus. As expected, antibodies against mucosal alphaHPV types were more frequent in younger patients and among women. Sunbed use and sunbathing was associated with seropositivity to multiple gammaHPV (P-trend = 0.007) and self-history of abnormal smear was related to seroactivity to multiple betaHPV (P = 0.01). Skin type and other self reported markers of exposure to ultraviolet radiation were not consistently associated with any HPV types. No other distinguishing epidemiological features of transplant recipients with antibodies against single or multiple HPV types were identified. Conclusion. Findings for mucosal HPV types were in line with results from previous studies. We observed differences in HPV seroprevalence between organ transplant recipients from two geographically close centres but no clear risk factor was found associated with cutaneous HPV seropositivity among organ transplant recipients. These findings have implications for interpretation of future seroepidemiology studies addressing the association between HPV and cutaneous SCC in OTR populations. © 2009 Casabonne et al; licensee BioMed Central Ltd.

引用

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