Gene expression associated with human brain activations in facial expression recognition

被引：0
作者：
Zirui Wang
Yuan Ji
Yumeng Fu
Feng Liu
Xin Du
Huaigui Liu
Wenshuang Zhu
Kaizhong Xue
Wen Qin
Quan Zhang
机构：
[1] Tianjin Medical University General Hospital,Department of Medical imaging and Tianjin Key Laboratory of Functional Imaging
来源：
Brain Imaging and Behavior | 2022年 / 16卷
关键词：
Emotion; Facial expression recognition; Magnetic resonance imaging; Gene expression; Allen Human Brain Atlas;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Previous studies identified some genetic loci of emotion, but few focused on human emotion-related gene expression. In this study, the facial expression recognition (FER) task-based high-resolution fMRI data of 203 subjects in the Human Connectome Project (HCP) and expression data of the six healthy human postmortem brain tissues in the Allen Human Brain Atlas (AHBA) were used to conduct a transcriptome-neuroimaging spatial association analysis. Finally, 371 genes were identified to be significantly associated with FER-related brain activations. Enrichment analyses revealed that FER-related genes were mainly expressed in the brain, especially neurons, and might be related to cell junction organization, synaptic functions, and nervous system development regulation, indicating that FER was a complex polygenetic biological process involving multiple pathways. Moreover, these genes exhibited higher enrichment for psychiatric diseases with heavy emotion impairments. This study provided new insight into understanding the FER-related biological mechanisms and might be helpful to explore treatment methods for emotion-related psychiatric disorders.
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页码：1657 / 1670
页数：13
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