Rp-cAMPS has ho effect on adenosine A1 receptors in guinea-pig cardiomyocytes

被引：0

作者：

Dawn L. Adamson

Sian E. Harding

机构：

[1] Imperial College of Science,

[2] Technology and Medicine,undefined

[3] National Heart and Lung Institute,undefined

[4] Dovehouse Street,undefined

[5] London SW3 6LY,undefined

[6] UK,undefined

[7] E-mail: d.adamson@ic.ac.uk,undefined

来源：

Basic Research in Cardiology | 2000年 / 95卷

关键词：

Key words Cardiomyocyte – beta-adrenoceptors – Rp-cAMPS – adenosine receptors – proteine kinase A;

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摘要：

Rp-cAMPS, a protein kinase A inhibitor, is used in the investigation of the cAMP-dependent systems. A report by Musgrave et al. (11) has suggested that Rp-cAMPS may also act on adenosine receptors. To determine whether this occurs in guinea-pig ventricular myocytes, Rp-cAMPS was applied in the presence and absence of DCPCX, an adenosine A1 receptor antagonist. The isoprenaline-induced response was significantly decreased by Rp-cAMPS and the effect was not altered by the presence of DCPCX. Therefore Rp-cAMPS has no effect on cell contraction via adenosine A1 receptors and can reliably be used to investigate cyclic AMP-dependent systems in isolated cardiac myocytes.

引用

页码：114 / 118

页数：4