Antimicrobial Surgical Sutures: Fabrication and Application of Infection Prevention and Wound Healing

Surgical sutures are considered to be a medical device for wound closure in healthcare applications. Surgical sutures maybe cause natural body response and form inflammation at the wound site of skin or organs after surgery, which play a negative role on wound healing. Within this context, it is necessary to develop antimicrobial surgical sutures with infection prevention and wound healing which can effectively inhibit the bacterial multiplication and improve healing rate. Currently, function agents made from natural or synthetic are being loaded in suture devices by various technique (such as coating, melt spinning, wet-spinning, grafting, electrospinning and blending) to produce antimicrobial surgical sutures. However, the properties of suture material determine the different modification technique. In this Review, we elaborate the preparation of antimicrobial surgical sutures for infection prevention and wound healing. Currently, most of antimicrobial surgical sutures still at researching and developing stage and few applied in clinically trials. Therefore, it is necessary to develop better antimicrobial sutures for preventing wound infection and promoting wound healing. The antimicrobial surgical sutures as a medical device will play a crucial role in the field of the anti-inflammatory and wound healing which mainly attribute to its unique properties, such as good biocompatibility, excellent antimicrobial, effective drug carrier, and amenability to various materials-design and manufacturing requires.