Histological composition and progression of carotid plaque

被引：6

作者：

Baroncini L.A.V. ^{[1
]}

Filho A.P. ^{[1
]}

Ramos S.G. ^{[2
]}

Martins A.R. ^{[3
]}

Murta Jr. L.O. ^{[4
]}

机构：

[1] Department of Internal Medicine, Faculdade de Medicina de Ribeirão Preto, University of São Paulo, São Paulo

[2] Department of Pathology, Faculdade de Medicina de Ribeirão Preto, University of São Paulo, São Paulo

[3] Department of Pharmacology, Faculdade de Medicina de Ribeirão Preto, University of São Paulo, São Paulo

[4] Department of Physics and Math, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, University of São Paulo, São Paulo

来源：

Thrombosis Journal | / 5卷 / 1期

关键词：

Carotid Plaque; Calcific Plaque; Internal Carotid Artery Stenosis; Carotid Artery Disease; Central Retinal Artery Occlusion;

D O I：

10.1186/1477-9560-5-4

中图分类号：

学科分类号：

摘要：

Background: To analyse histological composition and progression of carotid plaque. Methods: Thirty-one patients (22 males, mean age 68.03 ± 7.3 years) admitted for carotid endarterectomy for extracranial high-grade internal carotid artery stenosis (≥ 70% luminal narrowing) were enrolled. The patients were divided into 2 groups according to symptomatology (group I, 17 symptomatic patients; and group II, 14 asymptomatic patients). A histological analysis and inflammatory cell quantification of each excised carotid plaque was made. Nine carotid arteries were removed from human cadavers that were not preselected for carotid artery disease. These specimens were used as a control tissue without any macroscopic signs of atherosclerotic plaques. Results: Fifty eight percent of all carotid plaques were classified as complex plaque with possible surface defect, hemorrhage or thrombus. The inflammatory cells concentration did not differ between the two groups. All specimens from human cadavers were classified as preatheroma with extracellular lipid pools. Conclusion: Asymptomatic and symptomatic patients could have the same histological components on their carotid plaques. Fibrotic and calcific plaques could become vulnerable as complex plaques with surface defect, hemorrhage and thrombus could remain silent. Asymptomatic carotid stenosis should be followed close with no invasive diagnostic methods and clinical evaluation. © 2007 Baroncini et al; licensee BioMed Central Ltd.

引用

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