Role played by MDSC in colitis-associated colorectal cancer and potential therapeutic strategies

被引：2
|
作者：
Wang, Kang [1 ]
Wang, Yun [2 ]
Yin, Kai [3 ]
机构：
[1] Jiangsu Univ, Affiliated Hosp, Dept Gen Surg, Jiefang Rd 438, Zhenjiang 212000, Jiangsu, Peoples R China
[2] First Peoples Hosp Changzhou, Dept Dermatol, Juqian St, Changzhou 213003, Jiangsu, Peoples R China
[3] Jiangsu Univ, Affiliated Hosp, Inst Digest Dis, Dept Gen Surg, Jiefang Rd 438, Zhenjiang 212000, Jiangsu, Peoples R China
来源：
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 2024年 / 150卷 / 05期
基金：
中国国家自然科学基金;
关键词：
MDSC; Colitis-associated colorectal cancer; CRC; Targeting strategies; PHASE-II TRIAL; SUPPRESSOR-CELLS; OPEN-LABEL; MYELOID CELLS; CHEMOTHERAPY; PROMOTES; DIFFERENTIATION; MULTICENTER; BEVACIZUMAB; EFFICACY;
D O I：
10.1007/s00432-024-05755-w
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Colitis-associated colorectal cancer has been a hot topic in public health issues worldwide. Numerous studies have demonstrated the significance of myeloid-derived suppressor cells (MDSCs) in the progression of this ailment, but the specific mechanism of their role in the transformation of inflammation to cancer is unclear, and potential therapies targeting MDSC are also unclear. This paper outlines the possible involvement of MDSC to the development of colitis-associated colorectal cancer. It also explores the immune and other relevant roles played by MDSC, and collates relevant targeted therapies against MDSC. In addition, current targeted therapies for colorectal cancer are analyzed and summarized.
引用
收藏
页数：19
相关论文
共 50 条
  • [41] Differences between sporadic and colitis-associated colorectal cancer
    Itzkowitz, S. H.
    INTESTINAL INFLAMMATION AND COLORECTAL CANCER, 2007, 158 : 92 - 104
  • [42] Targeting a microRNA for the Therapy of Colitis-Associated Colorectal Cancer
    Polytarchou, Christos
    Hommes, Daniel W.
    Palumbo, Tiziana
    Hatziapostolou, Maria
    Koukos, Georgios
    van der Meulen-de Jong, Andrea E.
    Oikonomopoulos, Angelos
    van Deen, Welmoed K.
    Vorvis, Christina
    Koutsioumpa, Marina
    Birli, Eleni
    Choi, Jennifer M.
    Chang, Lin
    Anton, Peter
    Pothoulakis, Charalabos
    Verspaget, Hein W.
    Iliopoulos, Dimitrios
    GASTROENTEROLOGY, 2015, 148 (04) : S74 - S74
  • [43] The evolutionary history of human colitis-associated colorectal cancer
    Baker, Ann-Marie
    Cross, William
    Curtius, Kathleen
    Choi, Chang-ho Ryan
    Al-Bakir, Ibrahim
    Temko, Daniel
    Martinez, Pierre
    Williams, Marc
    Davis, Hayley
    Biswas, Sujata
    Wright, Nicholas A.
    Moorghen, Morgan
    Hayes, Stephen J.
    Rodriguez-Justo, Manuel
    Silver, Andrew
    Wang, Lai Mun
    Jansen, Marnix
    Hart, Ailsa L.
    Leedham, Simon J.
    Graham, Trevor A.
    CANCER RESEARCH, 2018, 78 (13)
  • [44] Surgical treatment in ulcerative colitis-associated colorectal cancer
    Heuschen, UA
    Stern, J
    Timmermanns, G
    Herfarth, C
    GASTROENTEROLOGY, 1996, 110 (04) : A528 - A528
  • [45] Evolutionary history of human colitis-associated colorectal cancer
    Baker, Ann-Marie
    Cross, William
    Curtius, Kit
    Al Bakir, Ibrahim
    Choi, Chang-Ho Ryan
    Davis, Hayley Louise
    Temko, Daniel
    Biswas, Sujata
    Martinez, Pierre
    Williams, Marc J.
    Lindsay, James O.
    Feakins, Roger
    Vega, Roser
    Hayes, Stephen J.
    Tomlinson, Ian P. M.
    McDonald, Stuart A. C.
    Moorghen, Morgan
    Silver, Andrew
    East, James E.
    Wright, Nicholas A.
    Wang, Lai Mun
    Rodriguez-Justo, Manuel
    Jansen, Marnix
    Hart, Ailsa L.
    Leedham, Simon J.
    Graham, Trevor A.
    GUT, 2019, 68 (06) : 985 - 995
  • [46] Yogurt Prevents Colitis-Associated Colorectal Cancer in Mice
    Li, Xiaojing
    Yan, Yongheng
    Du, Xinru
    Zhang, Hao
    Li, Haitao
    Chen, Wei
    MOLECULAR NUTRITION & FOOD RESEARCH, 2023,
  • [47] Early detection of ulcerative colitis-associated colorectal cancer
    Zhen, Yu
    Luo, Chengxin
    Zhang, Hu
    GASTROENTEROLOGY REPORT, 2018, 6 (02): : 83 - 92
  • [48] NLRP3 inflammasome in colitis and colitis-associated colorectal cancer
    Perera, Agampodi Promoda
    Sajnani, Karishma
    Dickinson, Joanne
    Eri, Rajaraman
    Korner, Heinrich
    MAMMALIAN GENOME, 2018, 29 (11-12) : 817 - 830
  • [49] Prevention of colitis and colitis-associated colorectal cancer by a novel small molecule
    Lin, Y. -T
    Wei, T. -T
    Tseng, R. -Y
    Shun, C. -T
    Lin, Y. -C
    Fang, J. -M
    Chen, C. -C
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2016, 46 : 409 - 409
  • [50] NLRP3 inflammasome in colitis and colitis-associated colorectal cancer
    Agampodi Promoda Perera
    Karishma Sajnani
    Joanne Dickinson
    Rajaraman Eri
    Heinrich Körner
    Mammalian Genome, 2018, 29 : 817 - 830
12345