Role played by MDSC in colitis-associated colorectal cancer and potential therapeutic strategies

被引：2
|
作者：
Wang, Kang [1 ]
Wang, Yun [2 ]
Yin, Kai [3 ]
机构：
[1] Jiangsu Univ, Affiliated Hosp, Dept Gen Surg, Jiefang Rd 438, Zhenjiang 212000, Jiangsu, Peoples R China
[2] First Peoples Hosp Changzhou, Dept Dermatol, Juqian St, Changzhou 213003, Jiangsu, Peoples R China
[3] Jiangsu Univ, Affiliated Hosp, Inst Digest Dis, Dept Gen Surg, Jiefang Rd 438, Zhenjiang 212000, Jiangsu, Peoples R China
来源：
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 2024年 / 150卷 / 05期
基金：
中国国家自然科学基金;
关键词：
MDSC; Colitis-associated colorectal cancer; CRC; Targeting strategies; PHASE-II TRIAL; SUPPRESSOR-CELLS; OPEN-LABEL; MYELOID CELLS; CHEMOTHERAPY; PROMOTES; DIFFERENTIATION; MULTICENTER; BEVACIZUMAB; EFFICACY;
D O I：
10.1007/s00432-024-05755-w
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Colitis-associated colorectal cancer has been a hot topic in public health issues worldwide. Numerous studies have demonstrated the significance of myeloid-derived suppressor cells (MDSCs) in the progression of this ailment, but the specific mechanism of their role in the transformation of inflammation to cancer is unclear, and potential therapies targeting MDSC are also unclear. This paper outlines the possible involvement of MDSC to the development of colitis-associated colorectal cancer. It also explores the immune and other relevant roles played by MDSC, and collates relevant targeted therapies against MDSC. In addition, current targeted therapies for colorectal cancer are analyzed and summarized.
引用
收藏
页数：19
相关论文
共 50 条
  • [21] Molecular mechanisms in colitis-associated colorectal cancer
    Royce W. Zhou
    Noam Harpaz
    Steven H. Itzkowitz
    Ramon E. Parsons
    Oncogenesis, 12
  • [22] Genetic risk for colitis-associated colorectal cancer
    Warren, Edus H.
    GUT, 2009, 58 (09) : 1177 - 1179
  • [23] Current overview of colitis-associated colorectal cancer
    Sobczak, Marta
    Wlazlowski, Marcin
    Zatorski, Hubert
    Salaga, Maciej
    Fichna, Jakub
    CENTRAL EUROPEAN JOURNAL OF BIOLOGY, 2014, 9 (11): : 1022 - 1029
  • [24] Genomic characterization of colitis-associated colorectal cancer
    Hitoshi Kameyama
    Masayuki Nagahashi
    Yoshifumi Shimada
    Yosuke Tajima
    Hiroshi Ichikawa
    Masato Nakano
    Jun Sakata
    Takashi Kobayashi
    Sumana Narayanan
    Kazuaki Takabe
    Toshifumi Wakai
    World Journal of Surgical Oncology, 16
  • [25] Genomic characterization of colitis-associated colorectal cancer
    Kameyama, Hitoshi
    Nagahashi, Masayuki
    Shimada, Yoshifumi
    Tajima, Yosuke
    Ichikawa, Hiroshi
    Nakano, Masato
    Sakata, Jun
    Kobayashi, Takashi
    Narayanan, Sumana
    Takabe, Kazuaki
    Wakai, Toshifumi
    WORLD JOURNAL OF SURGICAL ONCOLOGY, 2018, 16
  • [26] Inflammation and colorectal cancer: colitis-associated neoplasia
    Grivennikov, Sergei I.
    SEMINARS IN IMMUNOPATHOLOGY, 2013, 35 (02) : 229 - 244
  • [27] Inflammation and colorectal cancer: colitis-associated neoplasia
    Sergei I. Grivennikov
    Seminars in Immunopathology, 2013, 35 : 229 - 244
  • [28] THE ROLE OF CYCLOOXYGENASE IN COLITIS-ASSOCIATED CANCER
    Good, Hayley
    Shin, Alice E.
    Fazio, Elena N.
    Wang, Timothy C.
    Asfaha, Samuel
    GASTROENTEROLOGY, 2018, 154 (06) : S20 - S21
  • [29] Potential carcinogenic role of Reg IV in ulcerative colitis-associated colorectal neoplasia
    Zamzam, Yosra Abdelmonem
    Zamzam, Yomna
    Elsaka, Ayman
    Al Fadaly, Lamiaa
    Haydara, Tamer
    Amer, Alaa Ibraheem
    ECANCERMEDICALSCIENCE, 2024, 18
  • [30] Roles of macrophages on ulcerative colitis and colitis-associated colorectal cancer
    Zhang, Maorun
    Li, Xiaoping
    Zhang, Qi
    Yang, Jiahua
    Liu, Gang
    FRONTIERS IN IMMUNOLOGY, 2023, 14
12345