Role played by MDSC in colitis-associated colorectal cancer and potential therapeutic strategies

被引：2
|
作者：
Wang, Kang [1 ]
Wang, Yun [2 ]
Yin, Kai [3 ]
机构：
[1] Jiangsu Univ, Affiliated Hosp, Dept Gen Surg, Jiefang Rd 438, Zhenjiang 212000, Jiangsu, Peoples R China
[2] First Peoples Hosp Changzhou, Dept Dermatol, Juqian St, Changzhou 213003, Jiangsu, Peoples R China
[3] Jiangsu Univ, Affiliated Hosp, Inst Digest Dis, Dept Gen Surg, Jiefang Rd 438, Zhenjiang 212000, Jiangsu, Peoples R China
来源：
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 2024年 / 150卷 / 05期
基金：
中国国家自然科学基金;
关键词：
MDSC; Colitis-associated colorectal cancer; CRC; Targeting strategies; PHASE-II TRIAL; SUPPRESSOR-CELLS; OPEN-LABEL; MYELOID CELLS; CHEMOTHERAPY; PROMOTES; DIFFERENTIATION; MULTICENTER; BEVACIZUMAB; EFFICACY;
D O I：
10.1007/s00432-024-05755-w
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Colitis-associated colorectal cancer has been a hot topic in public health issues worldwide. Numerous studies have demonstrated the significance of myeloid-derived suppressor cells (MDSCs) in the progression of this ailment, but the specific mechanism of their role in the transformation of inflammation to cancer is unclear, and potential therapies targeting MDSC are also unclear. This paper outlines the possible involvement of MDSC to the development of colitis-associated colorectal cancer. It also explores the immune and other relevant roles played by MDSC, and collates relevant targeted therapies against MDSC. In addition, current targeted therapies for colorectal cancer are analyzed and summarized.
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页数：19
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