Impact of statin therapy on mortality in patients with sepsis-associated acute respiratory distress syndrome (ARDS) depends on ARDS severity: a prospective observational cohort study

Rubenfeld GD(2005)Incidence and outcomes of acute lung injury N Engl J Med 353 1685-93

Caldwell E(1994)The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination Am J Respir Crit Care Med 149 818-24

Peabody E(2008)Pharmacotherapy of acute lung injury and acute respiratory distress syndrome Curr Med Chem 15 1911-24

Weaver J(2005)Simvastatin attenuates vascular leak and inflammation in murine inflammatory lung injury Am J Physiol Lung Cell Mol Physiol 288 L1026-32

Martin DP(2005)Anti-inflammatory effects of statins: clinical evidence and basic mechanisms Nat Rev Drug Discov 4 977-87

Neff M(2009)Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers Am J Respir Crit Care Med 179 1107-14

Bernard GR(2004)Prior statin therapy is associated with a decreased rate of severe sepsis Circulation 110 880-5

Artigas A(2011)A randomized clinical trial of hydroxymethylglutaryl- coenzyme a reductase inhibition for acute lung injury (The HARP Study) Am J Respir Crit Care Med 183 620-6

Brigham KL(2001)The effect of statins on mortality in patients with bacteremia Clin Infect Dis 33 1352-7

Carlet J(2006)Statin use and mortality within 180 days after bacteremia: a population-based cohort study Crit Care Med 34 1080-6

Rubenfeld GD(2005)Incidence and outcomes of acute lung injury N Engl J Med 353 1685-93

Caldwell E(1994)The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination Am J Respir Crit Care Med 149 818-24

Peabody E(2008)Pharmacotherapy of acute lung injury and acute respiratory distress syndrome Curr Med Chem 15 1911-24

Weaver J(2005)Simvastatin attenuates vascular leak and inflammation in murine inflammatory lung injury Am J Physiol Lung Cell Mol Physiol 288 L1026-32

Martin DP(2005)Anti-inflammatory effects of statins: clinical evidence and basic mechanisms Nat Rev Drug Discov 4 977-87

Neff M(2009)Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers Am J Respir Crit Care Med 179 1107-14

Bernard GR(2004)Prior statin therapy is associated with a decreased rate of severe sepsis Circulation 110 880-5

Artigas A(2011)A randomized clinical trial of hydroxymethylglutaryl- coenzyme a reductase inhibition for acute lung injury (The HARP Study) Am J Respir Crit Care Med 183 620-6

Brigham KL(2001)The effect of statins on mortality in patients with bacteremia Clin Infect Dis 33 1352-7

Carlet J(2006)Statin use and mortality within 180 days after bacteremia: a population-based cohort study Crit Care Med 34 1080-6