Measurement of SARS-CoV-2 RNA in wastewater tracks community infection dynamics

被引：0

作者：

Jordan Peccia

Alessandro Zulli

Doug E. Brackney

Nathan D. Grubaugh

Edward H. Kaplan

Arnau Casanovas-Massana

Albert I. Ko

Amyn A. Malik

Dennis Wang

Mike Wang

Joshua L. Warren

Daniel M. Weinberger

Wyatt Arnold

Saad B. Omer

机构：

[1] Yale University,Department of Chemical and Environmental Engineering, School of Engineering and Applied Science

[2] State of Connecticut,Connecticut Agricultural Experimental Station

[3] Yale University,Department of Epidemiology of Microbial Disease, School of Public Health

[4] Yale School of Public Health,Public Health Modeling

[5] Yale University,School of Management

[6] Yale School of Medicine,Department of Biostatistics, Yale School of Public Health

[7] Yale Institute for Global Health,undefined

[8] Yale University,undefined

[9] Yale School of Nursing,undefined

来源：

Nature Biotechnology | 2020年 / 38卷

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摘要：

We measured severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA concentrations in primary sewage sludge in the New Haven, Connecticut, USA, metropolitan area during the Coronavirus Disease 2019 (COVID-19) outbreak in Spring 2020. SARS-CoV-2 RNA was detected throughout the more than 10-week study and, when adjusted for time lags, tracked the rise and fall of cases seen in SARS-CoV-2 clinical test results and local COVID-19 hospital admissions. Relative to these indicators, SARS-CoV-2 RNA concentrations in sludge were 0–2 d ahead of SARS-CoV-2 positive test results by date of specimen collection, 0–2 d ahead of the percentage of positive tests by date of specimen collection, 1–4 d ahead of local hospital admissions and 6–8 d ahead of SARS-CoV-2 positive test results by reporting date. Our data show the utility of viral RNA monitoring in municipal wastewater for SARS-CoV-2 infection surveillance at a population-wide level. In communities facing a delay between specimen collection and the reporting of test results, immediate wastewater results can provide considerable advance notice of infection dynamics.

引用

页码：1164 / 1167

页数：3

共 25 条

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