Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer

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[1] Section of Cancer Genetics,Department of Clinical Pharmacology

[2] Institute of Cancer Research,Department of Medical Genetics

[3] Molecular and Population Genetics,Strangeways Research Laboratory Department of Oncology

[4] Wellcome Trust Centre for Human Genetics,Department of General Internal Medicine

[5] Oxford University,Department of General and Thoracic Surgery

[6] Bioinformatics and Biostatistics,Division of Cancer Epidemiology

[7] Wellcome Trust Centre for Human Genetics,Division of Clinical Epidemiology and Aging Research

[8] Genome-Scale Biology Research Program,Division of Epidemiology

[9] Biomedicum Helsinki,undefined

[10] University of Helsinki,undefined

[11] Colon Cancer Genetics Group,undefined

[12] Institute of Genetics and Molecular Medicine,undefined

[13] University of Edinburgh and MRC Human Genetics Unit,undefined

[14] Clinical Genetics,undefined

[15] Western General Hospital,undefined

[16] Cancer Research UK Laboratories,undefined

[17] University of Cambridge,undefined

[18] University Hospital,undefined

[19] Schleswig-Holstein,undefined

[20] Campus Kiel,undefined

[21] Schittenhelmstraße 12,undefined

[22] POPGEN Biobank,undefined

[23] University Hospital Schleswig-Holstein,undefined

[24] Campus Kiel,undefined

[25] Schittenhelmstrasse 12,undefined

[26] University Hospital Schleswig-Holstein,undefined

[27] Campus Kiel,undefined

[28] Arnold-Heller-Strasse,undefined

[29] Institute for Clinical Molecular Biology,undefined

[30] University Hospital Schleswig-Holstein,undefined

[31] Campus Kiel,undefined

[32] Schittenhelmstrasse 12,undefined

[33] Institut für Epidemiologie und Sozialmedizin,undefined

[34] University Hospital Greifswald,undefined

[35] Walther-Rathenau-Strasse 48,undefined

[36] German Cancer Research Center (DKFZ),undefined

[37] Im Neuenheimer Feld 280,undefined

[38] German Cancer Research Center (DKFZ),undefined

[39] Im Neuenheimer Feld 280,undefined

[40] The Ottawa Health Research Institute,undefined

[41] The McGill University and Genome Quebec Innovation Centre,undefined

[42] Cancer Care Ontario,undefined

[43] 620 University Avenue,undefined

[44] Toronto Ontario M5G 1L7 and Ontario Institute for Cancer Research,undefined

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Nature Genetics | 2008年 / 40卷

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摘要：

Richard Houlston and colleagues identify four new susceptibility loci for colorectal cancer through a meta-analysis of genome-wide association data, followed by replication testing in a large collection of independent samples. The study brings to ten the number of confirmed loci harboring low-penetrance risk alleles for this common malignancy.

引用

页码：1426 / 1435

页数：9

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