Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection

被引：0
作者：
Davide Botta
Michael J Fuller
Tatiana T Marquez-Lago
Holly Bachus
John E Bradley
Amy S Weinmann
Allan J Zajac
Troy D Randall
Frances E Lund
Beatriz León
André Ballesteros-Tato
机构：
[1] University of Alabama at Birmingham,Department of Microbiology
[2] University of Alabama at Birmingham,Department of Medicine, Division of Clinical Immunology and Rheumatology
[3] Informatics Institute,Department of Genetics
[4] University of Alabama at Birmingham,undefined
[5] University of Alabama at Birmingham,undefined
来源：
Nature Immunology | 2017年 / 18卷
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摘要：
Humoral immunity is necessary for controlling viral infection. Ballesteros-Tato and colleagues show that development of follicular regulatory T cells is prevented by high concentrations of interleukin 2 at the peak of viral infection, but resumes at later time points to suppress autoantibody production.
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页码：1249 / 1260
页数：11
相关论文
共 129 条
[1]  
Yuan X(2014)The importance of regulatory T-cell heterogeneity in maintaining self-tolerance Immunol. Rev. 259 103-114
[2]  
Cheng G(2008)A two-step process for thymic regulatory T cell development Immunity 28 100-111
[3]  
Malek TR(2007)IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells J. Immunol. 178 280-290
[4]  
Lio CW(2007)Nonredundant roles for Stat5a/b in directly regulating Foxp3 Blood 109 4368-4375
[5]  
Hsieh CS(2005)A function for interleukin 2 in Foxp3-expressing regulatory T cells Nat. Immunol. 6 1142-1151
[6]  
Burchill MA(2005)Development and function of agonist-induced CD25 Nat. Immunol. 6 1152-1159
[7]  
Yang J(2013)Foxp3 J. Immunol. 190 1567-1575
[8]  
Vogtenhuber C(2004) regulatory T cells in the absence of interleukin 2 signaling Eur. J. Immunol. 34 2480-2488
[9]  
Blazar BR(1993)IL-2R signaling is essential for functional maturation of regulatory T cells during thymic development Cell 75 253-261
[10]  
Farrar MA(2014)Interleukin-2 is essential for CD4 Nat. Commun. 5 3495-1362
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