Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection

被引:0
作者
Davide Botta
Michael J Fuller
Tatiana T Marquez-Lago
Holly Bachus
John E Bradley
Amy S Weinmann
Allan J Zajac
Troy D Randall
Frances E Lund
Beatriz León
André Ballesteros-Tato
机构
[1] University of Alabama at Birmingham,Department of Microbiology
[2] University of Alabama at Birmingham,Department of Medicine, Division of Clinical Immunology and Rheumatology
[3] Informatics Institute,Department of Genetics
[4] University of Alabama at Birmingham,undefined
[5] University of Alabama at Birmingham,undefined
来源
Nature Immunology | 2017年 / 18卷
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摘要
Humoral immunity is necessary for controlling viral infection. Ballesteros-Tato and colleagues show that development of follicular regulatory T cells is prevented by high concentrations of interleukin 2 at the peak of viral infection, but resumes at later time points to suppress autoantibody production.
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页码:1249 / 1260
页数:11
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