Adiponectin gene polymorphism and its association with type 2 diabetes mellitus

被引：18
|
作者：
Biswas D. [1 ,3 ]
Vettriselvi V. [2 ]
Choudhury J. [1 ]
Jothimalar R. [1 ]
机构：
[1] Department of Biochemistry, Sri Ramachandra Medical College and Research Institute, Chennai 600116, Tamilnadu
[2] Department of Human Genetics, Sri Ramachandra Medical College and Research Institute, Chennai 600116, Tamilnadu
[3] Department of Biochemistry, ACS Medical College, Velappanchavadi, Chennai 600077, Tamilnadu
来源：
Indian Journal of Clinical Biochemistry | 2011年 / 26卷 / 2期
关键词：
Adiponectin gene; Polymorphism; Type; 2; diabetes;
D O I：
10.1007/s12291-011-0123-5
中图分类号：
学科分类号：
摘要：
Mutations in different regions of adiponectin gene have been reported to be associated with obesity, atherosclerosis and type 2 diabetes mellitus. The present study was aimed to investigate the association among SNP 45 T > G of adiponectin gene and type 2 diabetes in South Indian population. 75 clinically diagnosed case of type 2 diabetes were studied and compared with 75 apparently healthy controls. The genotype frequency of SNP45 T > G in exon 2 of adiponectin gene was determined by PCR based restriction enzyme analysis using the restriction enzyme SmaI. (recognition site: CCC↓GGG). Three kind of genotypes: wild type TT (470 bp), heterozygous type TG (470 bp, 336 bp, 134 bp) and homozygote mutant type GG (336 bp, 134 bp) were studied. A positive association has been found between SNP45 T > G and type 2 diabetes in the study population (P = 0.010, OR = 3.797, 95% CI = 1.312-10.983). Therefore, SNP45T > G in adiponectin gene may be one of the risk factors for type 2 diabetes. © Association of Clinical Biochemists of India 2011.
引用
收藏
页码：172 / 177
页数：5
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