HIV-1 infection and AIDS: consequences for the central nervous system

被引:0
作者
M Kaul
J Zheng
S Okamoto
H E Gendelman
S A Lipton
机构
[1] The Burnham Institute,Center for Neuroscience and Aging Research
[2] University of Nebraska Medical Center,Departments of Pharmacology and Pathology and Microbiology, Center for Neurovirology and Neurodegenerative Disorders, 985880 Nebraska Medical Center
来源
Cell Death & Differentiation | 2005年 / 12卷
关键词
HIV-1; NeuroAIDS; neurodegeneration; apoptosis; immune activation; macrophages/microglia; neurotoxicity; pharmacology; inflammation; central nervous system;
D O I
暂无
中图分类号
学科分类号
摘要
Infection with the human immunodeficiency virus-1 (HIV-1) can induce severe and debilitating neurological problems that include behavioral abnormalities, motor dysfunction and frank dementia. After infiltrating peripheral immune competent cells, in particular macrophages, HIV-1 provokes a neuropathological response involving all cell types in the brain. HIV-1 also incites activation of chemokine receptors, inflammatory mediators, extracellular matrix-degrading enzymes and glutamate receptor-mediated excitotoxicity, all of which can trigger numerous downstream signaling pathways and disrupt neuronal and glial function. This review will discuss recently uncovered pathologic neuroimmune and degenerative mechanisms contributing to neuronal damage induced by HIV-1 and potential approaches for development of future therapeutic intervention.
引用
收藏
页码:878 / 892
页数:14
相关论文
共 50 条
[21]   An immunovirological study of central nervous system involvement during HIV-1 infection of chimpanzees [J].
Grimaldi, LME ;
Murthy, KK ;
Martino, G ;
Furlan, R ;
Franciotta, D ;
Eichberg, JW .
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY, 1996, 13 (01) :12-17
[22]   HIV Infection and the Central Nervous System: A Primer [J].
Ellis, Ronald J. ;
Calero, Patricia ;
Stockin, Michael D. .
NEUROPSYCHOLOGY REVIEW, 2009, 19 (02) :144-151
[23]   Central Nervous System Compartmentalization of HIV-1 Subtype C Variants Early and Late in Infection in Young Children [J].
Sturdevant, Christa Buckheit ;
Dow, Anna ;
Jabara, Cassandra B. ;
Joseph, Sarah B. ;
Schnell, Gretja ;
Takamune, Nobutoki ;
Mallewa, Macpherson ;
Heyderman, Robert S. ;
Van Rie, Annelies ;
Swanstrom, Ronald .
PLOS PATHOGENS, 2012, 8 (12)
[24]   HIV-1 and its causal relationship to immunosuppression and nervous system disease in AIDS: A review [J].
Sotrel, A ;
Dal Canto, MC .
HUMAN PATHOLOGY, 2000, 31 (10) :1274-1298
[25]   Switching from a regimen containing abacavir/lamivudine or emtricitabine/tenofovir disoproxil fumarate to emtricitabine/tenofovir alafenamide fumarate does not affect central nervous system HIV-1 infection [J].
Yilmaz, Aylin ;
Mellgren, Asa ;
Fuchs, Dietmar ;
Nilsson, Staffan ;
Blennow, Kaj ;
Zetterberg, Henrik ;
Gisslen, Magnus .
INFECTIOUS DISEASES, 2019, 51 (11-12) :838-846
[26]   Interactions between prostaglandins, leukotrienes and HIV-1: Possible implications for the central nervous system [J].
Jonathan Bertin ;
Corinne Barat ;
Sylvie Méthot ;
Michel J Tremblay .
Retrovirology, 9
[27]   Interactions between prostaglandins, leukotrienes and HIV-1: Possible implications for the central nervous system [J].
Bertin, Jonathan ;
Barat, Corinne ;
Methot, Sylvie ;
Tremblay, Michel J. .
RETROVIROLOGY, 2012, 9
[28]   Central and peripheral nervous system functions are independently disturbed in HIV-1 infected patients [J].
von Giesen, HJ ;
Köller, H ;
Hefter, H ;
Arendt, G .
JOURNAL OF NEUROLOGY, 2002, 249 (06) :754-758
[29]   Interaction between Tat and Drugs of Abuse during HIV-1 Infection and Central Nervous System Disease [J].
Maubert, Monique E. ;
Pirrone, Vanessa ;
Rivera, Nina T. ;
Wigdahl, Brian ;
Nonnemacher, Michael R. .
FRONTIERS IN MICROBIOLOGY, 2016, 6
[30]   Characterization of Macrophage-Tropic HIV-1 Infection of Central Nervous System Cells and the Influence of Inflammation [J].
Woodburn, Blaide M. ;
Kanchi, Krishna ;
Zhou, Shuntai ;
Colaianni, Nicholas ;
Joseph, Sarah B. ;
Swanstrom, Ronald .
JOURNAL OF VIROLOGY, 2022, 96 (17)