Nitric Oxide and HSP70 Proteins during Normal Pregnancy, Gestosis, and Preclinical Gestosis

We measured the content of NO metabolites in blood plasma and urine and concentration of HSP70 proteins in the plasma and leukocytes from 126 women with normal pregnancy, gestosis, and preclinical gestosis. In women with gestosis accompanied by NO deficiency the concentration of HSP70 proteins in the plasma increased more significantly than in leukocytes. These changes are an important marker of endothelial dysfunction and reflect the severity of cell damage during this disorder. The decrease in excretion of NO in the urine and increase in HSP70 protein content in leukocytes and plasma characterize endothelial dysfunction in women with preclinical gestosis.