Effect of alpha-fetoprotein on lifespan of old mice

被引：0
作者：
V. N. Krut’ko
V. I. Dontsov
A. V. Khalyavkin
机构：
[1] Russian Academy of Sciences,Institute for Systems Analysis, Federal Research Center “Computer Science and Control”
[2] Sechenov First Moscow State Medical University,undefined
来源：
Biochemistry (Moscow) | 2016年 / 81卷
关键词：
age; alpha-fetoprotein; life extension;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Alpha-fetoprotein (AFP) is one of the best-known embryo-specific proteins. It is used to diagnose fetal abnormalities and tumors of the gastrointestinal tract and liver. AFP has pronounced immunotropic and detoxifying effect and a direct apoptotic effect on tumor cells. The treatment of mice at the oldest age in our experiments with AFP dramatically increased the survival and markedly increased the relative weight of immunotropic organs, apparently due to the general effect of AFP in improving functions of tissues and detoxifying actions. It also improved appearance and the relative weight of internal organs with a reduced age of autoaggression.
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页码：1477 / 1479
页数：2
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